丹麦肺炎支原体感染的十年半血清流行病学研究
Ten and a half years seroepidemiology of Mycoplasma pneumoniae infection in Denmark.
作者信息
Lind K, Bentzon M W
机构信息
Neisseria Department, Statens Seruminstitut, Copenhagen, Denmark.
出版信息
Epidemiol Infect. 1991 Aug;107(1):189-99. doi: 10.1017/s0950268800048810.
Abstract
The study was based on a computerized card index of 9161 patients who had at least one positive blood specimen in the Mycoplasma pneumoniae complement fixation test. A total of 12,562 specimens from these patients had been sent to Statens Seruminstitut from hospitals and general practitioners during a 10.5-year period. The period encompassed a previously described endemic period in a 30-year study of the epidemiological pattern of M. pneumoniae infection in Denmark. The serological data presented support the hypothesis advanced here that a more than sixfold increase of children in day care might have contributed to a change in the epidemiological pattern. The correlation between age and level of specific antibodies, as well as persistence of seropositivity, were also investigated.
摘要
该研究基于一个计算机化的卡片索引，涉及9161名患者，这些患者在肺炎支原体补体结合试验中至少有一份血液标本呈阳性。在10.5年的时间里，这些患者共有12562份标本从医院和全科医生处被送到丹麦国家血清研究所。这一时期涵盖了丹麦一项为期30年的肺炎支原体感染流行病学模式研究中先前描述的流行期。所呈现的血清学数据支持了此处提出的假设，即日托机构中儿童数量增加超过六倍可能导致了流行病学模式的变化。同时还研究了年龄与特异性抗体水平之间的相关性以及血清阳性的持续情况。
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