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本文引用的文献

1
The role of nitrogen oxides as effector molecules of parasite killing.氮氧化物作为寄生虫杀伤效应分子的作用。
Parasitol Today. 1990 Sep;6(9):303-5. doi: 10.1016/0169-4758(90)90261-2.
2
Killing of Mycobacterium microti by immunologically activated macrophages.免疫激活的巨噬细胞对微小分枝杆菌的杀伤作用。
Nature. 1981 Sep 3;293(5827):69-71. doi: 10.1038/293069a0.
3
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.生物体液中硝酸盐、亚硝酸盐和[15N]硝酸盐的分析。
Anal Biochem. 1982 Oct;126(1):131-8. doi: 10.1016/0003-2697(82)90118-x.
4
The contribution of hydrogen peroxide resistance to virulence of Mycobacterium tuberculosis during the first six days after intravenous infection of normal and BCG-vaccinated guinea-pigs.过氧化氢抗性对结核分枝杆菌在静脉感染正常和卡介苗接种豚鼠后前六天毒力的贡献。
Br J Exp Pathol. 1981 Feb;62(1):34-40.
5
Guinea pig alveolar macrophages probably kill M. tuberculosis H37Rv and H37Ra in vivo by producing hydrogen peroxide.
Adv Exp Med Biol. 1983;162:99-104. doi: 10.1007/978-1-4684-4481-0_10.
6
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.哺乳动物硝酸盐生物合成：小鼠巨噬细胞在响应大肠杆菌脂多糖时产生亚硝酸盐和硝酸盐。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7738-42. doi: 10.1073/pnas.82.22.7738.
7
Comparative biology of intracellular parasitism.细胞内寄生的比较生物学
Microbiol Rev. 1985 Sep;49(3):298-337. doi: 10.1128/mr.49.3.298-337.1985.
8
Growth requirements of murine bone marrow macrophages in serum-free cell culture.无血清细胞培养中小鼠骨髓巨噬细胞的生长需求
Immunobiology. 1986 Mar;171(1-2):14-26. doi: 10.1016/S0171-2985(86)80014-6.
9
Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.小鼠巨噬细胞抑菌活性对特定氨基酸（L-精氨酸）的需求。
J Clin Invest. 1988 Apr;81(4):1129-36. doi: 10.1172/JCI113427.
10
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.巨噬细胞将L-精氨酸氧化为亚硝酸盐和硝酸盐：一氧化氮是中间产物。
Biochemistry. 1988 Nov 29;27(24):8706-11. doi: 10.1021/bi00424a003.

γ干扰素激活的骨髓巨噬细胞抑制分枝杆菌生长的机制：活性氮中间体的作用

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates.

作者信息

Flesch I E, Kaufmann S H

机构信息

Department of Immunology, University of Ulm, Federal Republic of Germany.

出版信息

Infect Immun. 1991 Sep;59(9):3213-8. doi: 10.1128/iai.59.9.3213-3218.1991.

DOI:10.1128/iai.59.9.3213-3218.1991
PMID:1908829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258155/
Abstract

Murine bone marrow-derived macrophages are able to inhibit the growth of Mycobacterium bovis after stimulation with recombinant gamma interferon. This antimycobacterial activity was inhibited by NG-monomethyl-L-arginine, a specific inhibitor of nitrite and nitrate synthesis from L-arginine. Furthermore, there was a complete lack of mycobacterial growth inhibition in a medium deficient in L-arginine. Nitrite is generated by gamma interferon-activated bone marrow-derived macrophages after infection with M. bovis, and a correlation between mycobacterial growth inhibition and nitrite production was observed. These results indicate that reactive nitrogen intermediates derived from L-arginine are crucially involved in macrophage antimycobacterial activity.

摘要

用重组γ干扰素刺激后，小鼠骨髓来源的巨噬细胞能够抑制牛分枝杆菌的生长。L-精氨酸合成亚硝酸盐和硝酸盐的特异性抑制剂NG-单甲基-L-精氨酸可抑制这种抗分枝杆菌活性。此外，在缺乏L-精氨酸的培养基中，完全没有分枝杆菌生长抑制现象。γ干扰素激活的骨髓来源巨噬细胞在感染牛分枝杆菌后会产生亚硝酸盐，并且观察到分枝杆菌生长抑制与亚硝酸盐产生之间存在相关性。这些结果表明，源自L-精氨酸的活性氮中间体在巨噬细胞抗分枝杆菌活性中起关键作用。