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2
Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.干扰素-γ激活的骨髓巨噬细胞对分枝杆菌生长的抑制作用以及结核分枝杆菌菌株间的易感性差异
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本文引用的文献

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Enchancement of experimental tuberculosis in the mouse by suramin.苏拉明增强小鼠实验性结核病
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Killing of Mycobacterium microti by immunologically activated macrophages.免疫激活的巨噬细胞对微小分枝杆菌的杀伤作用。
Nature. 1981 Sep 3;293(5827):69-71. doi: 10.1038/293069a0.
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Lymphokine-mediated microbistatic mechanisms restrict Chlamydia psittaci growth in macrophages.淋巴因子介导的微生物抑制机制限制了鹦鹉热衣原体在巨噬细胞中的生长。
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The role of cell-mediated immunity in bacterial infections.细胞介导的免疫在细菌感染中的作用。
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The contribution of hydrogen peroxide resistance to virulence of Mycobacterium tuberculosis during the first six days after intravenous infection of normal and BCG-vaccinated guinea-pigs.过氧化氢抗性对结核分枝杆菌在静脉感染正常和卡介苗接种豚鼠后前六天毒力的贡献。
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Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.γ干扰素通过诱导宿主细胞降解色氨酸来阻断弓形虫在人成纤维细胞中的生长。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):908-12. doi: 10.1073/pnas.81.3.908.
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Guinea pig alveolar macrophages probably kill M. tuberculosis H37Rv and H37Ra in vivo by producing hydrogen peroxide.
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Automated colorimetric assay for T cell cytotoxicity.T细胞细胞毒性的自动化比色测定法。
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Comparative biology of intracellular parasitism.细胞内寄生的比较生物学
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Antigen-specific Lyt-2+ cytolytic T lymphocytes from mice infected with the intracellular bacterium Listeria monocytogenes.来自感染细胞内细菌单核细胞增生李斯特菌的小鼠的抗原特异性Lyt-2 + 细胞溶解性T淋巴细胞。
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对γ-干扰素激活的骨髓巨噬细胞抑制分枝杆菌生长所涉及机制的研究尝试。

Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages.

作者信息

Flesch I E, Kaufmann S H

机构信息

Max-Planck-Institut für Immunbiologie, Freiburg, Federal Republic of Germany.

出版信息

Infect Immun. 1988 Jun;56(6):1464-9. doi: 10.1128/iai.56.6.1464-1469.1988.

DOI:10.1128/iai.56.6.1464-1469.1988
PMID:2453466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259422/
Abstract

Bone marrow-derived murine macrophages are able to inhibit the growth of Mycobacterium bovis and of some strains of M. tuberculosis after stimulation with either recombinant gamma interferon (rIFN-gamma) or lymphokines from antigen-specific T-cell clones. To elucidate the mechanism(s) involved in antimycobacterial activity, macrophages were infected with M. bovis in the presence of agents thought to influence the antimicrobial effects of phagocytes. Scavengers of toxic oxygen metabolites failed to influence the capacity of IFN-gamma-activated bone marrow macrophages to inhibit the growth of M. bovis. Suramin slightly affected mycobacterial growth in IFN-gamma-activated macrophages, and chloroquine markedly induced growth inhibition of M. bovis in unstimulated macrophages. We conclude that growth inhibition of M. bovis by IFN-gamma-activated macrophages is an oxygen-independent process.

摘要

骨髓来源的小鼠巨噬细胞在用重组γ干扰素（rIFN-γ）或抗原特异性T细胞克隆产生的淋巴因子刺激后，能够抑制牛分枝杆菌和某些结核分枝杆菌菌株的生长。为了阐明参与抗分枝杆菌活性的机制，在存在被认为会影响吞噬细胞抗菌作用的试剂的情况下，用牛分枝杆菌感染巨噬细胞。有毒氧代谢产物的清除剂未能影响IFN-γ激活的骨髓巨噬细胞抑制牛分枝杆菌生长的能力。苏拉明对IFN-γ激活的巨噬细胞中的分枝杆菌生长有轻微影响，而氯喹显著诱导未刺激的巨噬细胞中牛分枝杆菌的生长抑制。我们得出结论，IFN-γ激活的巨噬细胞对牛分枝杆菌的生长抑制是一个不依赖氧的过程。