胆胰转流术的临床结果及营养后果：三年随访

Clinical results and nutritional consequences of biliopancreatic diversion: three years of follow-up.

作者信息

de Luis D A, Pacheco D, Izaola O, Terroba M C, Cuellar L, Martin T

机构信息

Institute of Endocrinology and Nutrition, Medical School, Unit of Investigation, Surgical Department, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.

出版信息

Ann Nutr Metab. 2008;53(3-4):234-9. doi: 10.1159/000185641. Epub 2008 Dec 16.

DOI:10.1159/000185641

PMID:19088468

Abstract

BACKGROUND

Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The aim of our work was to describe clinical results and nutritional complications in morbidly obese patients with biliopancreatic diversion.

METHODS

We have analyzed a consecutive series of 64 patients who have been followed up for 3 years after undergoing open biliopancreatic diversion by the Scopinaro technique.

RESULTS

Initial excess weight loss was 29.3% at 6 months and 61.5% at 3 years. A significant improvement of body mass index, weight, waist circumference, fat mass, glucose level, total cholesterol, uric acid and triglycerides levels was detected. Ferritin, vitamin A, vitamin D, vitamin B(12), zinc and copper levels showed a low percentage of deficiency at basal time, but during the follow-up, the percentage of deficiency increased. Vitamin E and K did not show basal deficiency. However, after surgery, a moderate deficiency of both vitamins was detected (vitamin E 7.1% and vitamin K 8.3%). Folic acid deficiency was observed in 54.3% of the subjects at basal time, but decreased during the study.

CONCLUSION

Biliopancreatic diversion is an effective method of sustainable weight loss. However, micronutrient deficiencies can occur.

摘要

背景

减重手术是治疗病态肥胖最有效的长期疗法，可减少与肥胖相关的合并症。我们研究的目的是描述接受胆胰转流术的病态肥胖患者的临床结果和营养并发症。

方法

我们分析了连续64例接受Scopinaro技术开放式胆胰转流术并随访3年的患者。

结果

最初的超重减轻在6个月时为29.3%，在3年时为61.5%。检测到体重指数、体重、腰围、脂肪量、血糖水平、总胆固醇、尿酸和甘油三酯水平有显著改善。铁蛋白、维生素A、维生素D、维生素B12、锌和铜水平在基线时缺乏比例较低，但在随访期间，缺乏比例增加。维生素E和维生素K在基线时未显示缺乏。然而，手术后，检测到这两种维生素均有中度缺乏（维生素E为7.1%，维生素K为8.3%）。在基线时，54.3%的受试者观察到叶酸缺乏，但在研究期间有所下降。