Forbes Sean C, Slade Jill M, Meyer Ronald A
Department of Physiology, Michigan State University, East Landing, MI 48824, USA.
Appl Physiol Nutr Metab. 2008 Dec;33(6):1124-31. doi: 10.1139/H08-099.
Previous studies have shown that high-intensity training improves biochemical markers of oxidative potential in skeletal muscle within a 2-week period. The purpose of this study was to examine the effect of short-term high-intensity interval training on the time constant () of phosphocreatine (PCr) recovery following moderate-intensity exercise, an in vivo measure of functional oxidative capacity. Seven healthy active subjects (age, 21 +/- 4 years; body mass, 69 +/- 11 kg) performed 6 sessions of 4-6 maximal-effort 30 s cycling intervals within a 2-week period, and 7 subjects (age, 24 +/- 5 years; body mass, 80 +/- 15 kg) served as controls. Prior to and following training, phosphorous-31 magnetic resonance spectroscopy (31P-MRS; GE 3T Excite System) was used to measure relative changes in high-energy phosphates and intracellular pH of the quadriceps muscles during gated dynamic leg-extension exercise (3 cycles of 90 s exercise and 5 min of rest). A monoexponential model was used to estimate the of PCr recovery. The of PCr recovery after leg-extension exercise was reduced by 14% with high-intensity interval training (pretraining, 43 +/- 14 s vs. post-training, 37 +/- 15 s; p < 0.05) with no change in the control group (44 +/- 12 s vs. 43 +/- 12 s, respectively; p > 0.05). These findings demonstrate that short-term high-intensity interval training is an effective means of increasing functional oxidative capacity in skeletal muscle.
先前的研究表明，高强度训练可在2周内改善骨骼肌氧化潜能的生化指标。本研究的目的是检验短期高强度间歇训练对中等强度运动后磷酸肌酸（PCr）恢复时间常数（）的影响，这是一种体内功能氧化能力的测量方法。7名健康的活跃受试者（年龄21±4岁；体重69±11 kg）在2周内进行了6次，每次包含4 - 6组持续30秒的最大努力骑行间歇训练，7名受试者（年龄24±5岁；体重80±15 kg）作为对照组。在训练前后，采用磷-31磁共振波谱法（31P-MRS；GE 3T Excite系统）测量在门控动态腿部伸展运动（90秒运动3个周期，休息5分钟）期间股四头肌高能磷酸盐和细胞内pH值的相对变化。采用单指数模型估算PCr恢复的。高强度间歇训练使腿部伸展运动后PCr恢复的时间常数降低了14%（训练前，43±14秒 vs. 训练后，37±15秒；p<0.05），而对照组无变化（分别为44±12秒 vs. 43±12秒；p>0.05）。这些发现表明，短期高强度间歇训练是增加骨骼肌功能氧化能力的有效手段。
