Luz Rentero Maria, Carbonell Cristina, Casillas Marta, González Béjar Milagros, Berenguer Rafael
Clinical Research Department, Lilly, SA, Madrid, Spain.
Open Rheumatol J. 2008;2:58-63. doi: 10.2174/1874312900802010058. Epub 2008 Nov 14.
Osteoporosis (OP) is a major, highly prevalent health problem and osteoporosis-related fractures account for high morbidity and mortality. Therefore, prevention and early detection of osteoporosis should strive to substantially reduce this risk of fracture.
The present observational, descriptive, cross-sectional study sought to assess the prevalence of risk factors for osteoporosis and fractures in a large sample of postmenopausal women aged 50 to 65 years attending Primary Care facilities in Spain.
We recruited 4,960 women, at 96 Primary Care centers. Demographic and anthropometrical data, as well as information regarding risk factors for OP were collected using a questionnaire.
the prevalence rates for the major osteoporosis risk factors in our population were: low calcium intake, 43%; benzodiazepine use, 35.1%, and height loss, 30.1%. Other relatively prevalent factors include: having suffered at least one fall during the preceding year; positive family history of falls (particularly on the mother's side), smoking, kyphosis, presence of any disease affecting bone metabolism, personal history of falls, and inability to rise from a chair without using one's arms. The least frequent factors were weight loss of greater than 10% over the preceding 10 years and problems in sensory perception that affect patient's ability to walk.
The main risk factors for osteoporosis in women 50-65 years of age are low calcium intake, use of benzodiazepines, and observed loss of height. Our results may help physicians to identify groups at risk for OP and fractures at early stages and consequently, optimize prevention and early diagnosis of osteoporosis in postmenopausal women.
骨质疏松症(OP)是一个主要的、高度普遍的健康问题,与骨质疏松症相关的骨折导致高发病率和死亡率。因此,骨质疏松症的预防和早期检测应致力于大幅降低这种骨折风险。
本观察性、描述性横断面研究旨在评估在西班牙初级保健机构就诊的50至65岁绝经后女性大样本中骨质疏松症和骨折风险因素的患病率。
我们在96个初级保健中心招募了4960名女性。使用问卷收集人口统计学和人体测量数据以及有关骨质疏松症风险因素的信息。
我们人群中主要骨质疏松症风险因素的患病率为:钙摄入量低,43%;使用苯二氮䓬类药物,35.1%,身高降低,30.1%。其他相对普遍的因素包括:在前一年至少跌倒过一次;跌倒家族史阳性(特别是母系)、吸烟、脊柱后凸、存在任何影响骨代谢的疾病、个人跌倒史以及不借助手臂无法从椅子上起身。最不常见的因素是在过去10年中体重减轻超过10%以及影响患者行走能力的感觉障碍问题。
50 - 65岁女性骨质疏松症的主要风险因素是钙摄入量低、使用苯二氮䓬类药物以及观察到的身高降低。我们的结果可能有助于医生在早期识别骨质疏松症和骨折的高危人群,从而优化绝经后女性骨质疏松症的预防和早期诊断。