Buttarelli Francesca R, Circella Annapia, Pellicano Clelia, Tiple Dorina, Giovannelli Morena, Colosimo Carlo, Pontieri Francesco E
Department of Neurological Sciences, University Sapienza, Rome, Italy.
J Neural Transm (Vienna). 2009 Feb;116(2):161-5. doi: 10.1007/s00702-008-0170-0. Epub 2008 Dec 17.
Previous studies showed the reduction of dopamine transporter immunoreactivity (DAT-IR) in peripheral blood lymphocytes (PBL) in Parkinson's disease. Here we report the reduction of DAT-IR in PBL in the extrapyramidal variant of multiple system atrophy. These results suggest the reduction of DAT-IR in PBL in a variety of neurodegenerative disorders, provided the presence of damage of the central dopaminergic systems. The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells.
先前的研究表明，帕金森病患者外周血淋巴细胞（PBL）中的多巴胺转运体免疫反应性（DAT-IR）降低。在此，我们报告多系统萎缩锥体外系变异型患者PBL中的DAT-IR降低。这些结果表明，只要存在中枢多巴胺能系统损伤，多种神经退行性疾病患者的PBL中DAT-IR都会降低。这些疾病中PBL中DAT-IR的降低可能代表一种代偿现象，旨在减少细胞内多巴胺内流，从而减少多巴胺介导的这些细胞氧化应激加重。
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