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一例椎体后凸成形术后的无菌性骨坏死

Postoperative aseptic osteonecrosis in a case of kyphoplasty.

作者信息

Mueller Michael, Daniels-Wredenhagen M, Besch L, Decher C, Seekamp A

机构信息

Department of Trauma, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 7, Kiel, Germany.

出版信息

Eur Spine J. 2009 Jul;18 Suppl 2(Suppl 2):213-6. doi: 10.1007/s00586-008-0843-2. Epub 2008 Dec 17.

Abstract

Aseptic osteonecrosis appears to be an infrequent adverse event after kyphoplasty which has not previously been reported. In the following, we present the case of a 73-year-old female who sustained a compression fracture of the first lumbar vertebra (L1) in a motor vehicle accident. The fracture was treated by kyphoplasty using PMMA cement. Three weeks after hospital discharge the patient was presented with increasing back pain. In imaging, dislocation of the PMMA cement could be shown combined with a total collapse of the L1 vertebra. The resulting significant kyphosis was first reduced by dorsal transpedicular (Th12-L2) internal fixation and stabilized by an anterior cage after total removal of the cement plomb and some remaining bone of the L1 vertebra. Bacterial as well as histological examination of the cement and bone led to the diagnosis of aseptic osteonecrosis. Different underlying events could be discussed. We think it most likely that the osteoporotic bone was unable to interface sufficiently with the PMMA cement and, therefore, disintegrated under loading. Furthermore, the volume of injected cement could have significantly compromised the blood supply within the bone.

摘要

无菌性骨坏死似乎是椎体后凸成形术后一种罕见的不良事件,此前尚无相关报道。在此,我们报告一例73岁女性患者,其在机动车事故中发生第一腰椎(L1)压缩性骨折。该骨折采用聚甲基丙烯酸甲酯(PMMA)骨水泥进行椎体后凸成形术治疗。出院三周后,患者出现背痛加重。影像学检查显示,PMMA骨水泥移位,同时L1椎体完全塌陷。首先通过胸12至腰2经椎弓根后路内固定术纠正由此导致的严重后凸畸形,在完全取出骨水泥块及L1椎体部分残留骨质后,通过前路椎间融合器进行稳定固定。对骨水泥和骨质进行细菌学及组织学检查后诊断为无菌性骨坏死。可以探讨不同的潜在病因。我们认为最有可能的原因是骨质疏松性骨质无法与PMMA骨水泥充分结合,因此在受力情况下发生崩解。此外,注入的骨水泥量可能严重影响了骨内血供。

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