RNA受到攻击：细胞对RNA损伤的处理
RNA under attack: cellular handling of RNA damage.
作者信息
Wurtmann Elisabeth J, Wolin Sandra L
机构信息
Department of Cell Biology, Yale University, New Haven, CT 06510, USA.
出版信息
Crit Rev Biochem Mol Biol. 2009 Jan-Feb;44(1):34-49. doi: 10.1080/10409230802594043.
Abstract
Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to elucidate the role of RNA turnover pathways and specific damage recognition pathways in clearing cells of these damaged RNAs.
摘要
紫外线、氧化、氯化、硝化和烷基化对RNA造成的损伤可包括对核碱基的化学修饰以及RNA-RNA和RNA-蛋白质交联。体外研究描述了一系列可能的损伤产物，其中一些在正常生长、应激条件或疾病状态下的体内观察结果支持其具有生理相关性。信使RNA和非编码RNA的损伤都可能产生功能后果，并且已经开始研究RNA周转途径和特定损伤识别途径在清除细胞中这些受损RNA方面的作用。
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