从长柄藤黄叶子中分离得到的三种新呫吨酮。

Three new xanthones from the leaves of Garcinia lancilimba.

作者信息

Sun Yating, Li Dahong, Jia Cuicui, Xue Chunmei, Bai Jiao, Li Zhanlin, Hua Huiming

机构信息

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.

出版信息

J Nat Med. 2016 Apr;70(2):173-8. doi: 10.1007/s11418-015-0950-4. Epub 2015 Dec 8.

DOI:10.1007/s11418-015-0950-4

PMID:26645396

Abstract

Three new prenylated xanthones, garcinexanthones G-I (1-3), together with fifteen known ones (4-18) were identified from the leaves of Garcinia lancilimba. Their structures were determined by extensive spectroscopic analyses. Most of the compounds exhibited inhibitory effects against HL-60 (human leukemia), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines. Among them, compounds 7, 17, and 13 exhibited the most pronounced growth inhibitory activity against HL-60, A549, and MCF-7 cell lines with GI50 values of 1.68, 4.88, and 6.28 μM, respectively.

摘要

从长柄藤黄的叶子中鉴定出三种新的异戊烯基呫吨酮，藤黄呫吨酮G - I（1 - 3），以及十五种已知的化合物（4 - 18）。通过广泛的光谱分析确定了它们的结构。大多数化合物对HL - 60（人白血病）、A549（人肺癌）和MCF - 7（人乳腺癌）细胞系表现出抑制作用。其中，化合物7、17和13对HL - 60、A549和MCF - 7细胞系表现出最显著的生长抑制活性，其GI50值分别为1.68、4.88和6.28 μM。