Finazzi-Agrò Enrico, Rocchi Camilla, Pachatz Christa, Petta Filomena, Spera Enrico, Mori Francesco, Sciobica Francesco, Marfia Girolama A
Department of Surgery, Chair of Urology, Tor Vergata University, Tor Vergata University Hospital, Rome, Italy.
Neurourol Urodyn. 2009;28(4):320-4. doi: 10.1002/nau.20651.
Long-latency somatosensory evoked potentials (LL-SEP) provide information on the function of somatosensory cortical structures. Percutaneous tibial nerve stimulation (PTNS) is indicated in the treatment of lower urinary tract dysfunction. Aim of this study was to evaluate LL-SEP in patients with overactive bladder syndrome (OAB) treated by means of PTNS.
Sixteen female patients with a diagnosis of pharmacoresistant OAB underwent PTNS while eight female patients with the same diagnosis underwent sham stimulation. LL-SEP were performed at baseline and at the end of PTNS or sham stimulation. Peak latency and peak to peak amplitude of P80, P100, and P200 waves were measured.
Mean latency of P80, P100, and P200 and mean amplitude of P200 did not show any significant change after both stimulation. Mean amplitude of P80 and P100 waves increased significantly after PTNS while it did not vary after sham stimulation.
The P80 and P100 amplitude increase might reflect long-term modifications in synaptic efficiency through the somatosensory pathway. The plastic reorganization of cortical network triggered by peripheral neuromodulation can be hypothesized as a mechanism of action of PTNS. Further studies are needed to correlate LL-SEP modifications after PTNS with the success of the treatment.
长潜伏期体感诱发电位（LL-SEP）可提供有关体感皮层结构功能的信息。经皮胫神经刺激（PTNS）用于治疗下尿路功能障碍。本研究的目的是评估经PTNS治疗的膀胱过度活动症（OAB）患者的LL-SEP。
16例诊断为药物抵抗性OAB的女性患者接受PTNS，而8例诊断相同的女性患者接受假刺激。在基线以及PTNS或假刺激结束时进行LL-SEP检查。测量P80、P100和P200波的峰潜伏期和峰峰值幅度。
两种刺激后，P80、P100和P200的平均潜伏期以及P200的平均幅度均未显示出任何显著变化。PTNS后P80和P100波的平均幅度显著增加，而假刺激后其没有变化。
P80和P100幅度增加可能反映了通过体感通路的突触效率的长期改变。可以假设由外周神经调节触发的皮层网络的可塑性重组是PTNS的一种作用机制。需要进一步研究以将PTNS后的LL-SEP改变与治疗成功相关联。
