Kayhan Basak, Arasli Mehmet, Eren Haci, Aydemir Selim, Kayhan Burcak, Aktas Elif, Tekin Ishak
Immunology Department, Faculty of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak, Turkey.
Microbiol Immunol. 2008 Nov;52(11):531-8. doi: 10.1111/j.1348-0421.2008.00066.x.
H. pylori elicits specific humoral and cellular immune responses in the mucosal immune system. However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While alphabeta TCR(+) lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan gammadelta TCR(+) lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed.
幽门螺杆菌在黏膜免疫系统中引发特定的体液和细胞免疫反应。然而，幽门螺杆菌阳性患者全身免疫系统中T淋巴细胞反应的类型和程度尚不清楚。在本研究中，分析了32例幽门螺杆菌阳性患者的外周血T淋巴细胞表型和基于血清Th1/Th2的细胞因子，并与健康对照者进行比较。虽然αβTCR(+)淋巴细胞及其表型分析与健康对照者无显著差异，但幽门螺杆菌阳性组中泛γδTCR(+)淋巴细胞的百分比比健康对照者高2.4倍。此外，幽门螺杆菌患者血清样本中IL-10浓度显著升高，表明其免疫系统已转向Th2型免疫反应。文中讨论了幽门螺杆菌感染期间外周血中T细胞反应的表型与类型之间的相关性。
