Mayo Clinic, Department of Health Sciences Research, Division of Epidemiology, 200 First Street SW, Rochester, MN 55905, United States.
Neurobiol Aging. 2010 Nov;31(11):1894-902. doi: 10.1016/j.neurobiolaging.2008.10.018. Epub 2008 Dec 16.
The progression of amnestic mild cognitive impairment (a-MCI) to Alzheimer's disease and hypothesized progression of non-amnestic mild cognitive impairment (na-MCI) to non-degenerative or vascular dementias suggest etiologic differences. We examined the association between coronary heart disease (CHD) and mild cognitive impairment (MCI) subtypes in a population-based cohort. Participants (n=1969; aged 70-89 years) were evaluated using the Clinical Dementia Rating Scale, a neurological examination, and neuropsychological testing for diagnoses of normal cognition, MCI, or dementia. CHD was defined as a history of myocardial infarction, angina, angiographic coronary stenosis, or coronary revascularization and ascertained by participant interview and from medical records. CHD was significantly associated with na-MCI (OR=1.93; 95% CI=1.22-3.06) but not with a-MCI (OR=0.94; 95% CI=0.69-1.28). In contrast, ApoE ɛ4 allele was significantly associated with a-MCI (OR=1.75; 95% CI=1.28-2.41), but not with na-MCI (OR=1.17; 95% CI=0.69-2.00). The association of CHD with prevalent na-MCI but not with a-MCI suggests that CHD and na-MCI may have similar underlying etiologies.
遗忘型轻度认知障碍 (a-MCI) 向阿尔茨海默病的进展和非遗忘型轻度认知障碍 (na-MCI) 向非退行性或血管性痴呆的假设进展表明存在病因学差异。我们在一个基于人群的队列中研究了冠心病 (CHD) 与轻度认知障碍 (MCI) 亚型之间的关联。参与者 (n=1969；年龄 70-89 岁) 使用临床痴呆评定量表、神经系统检查和神经心理学测试进行评估，以诊断正常认知、MCI 或痴呆。CHD 定义为心肌梗死、心绞痛、血管造影冠状动脉狭窄或冠状动脉血运重建的病史，并通过参与者访谈和医疗记录确定。CHD 与 na-MCI 显著相关 (OR=1.93；95% CI=1.22-3.06)，但与 a-MCI 不相关 (OR=0.94；95% CI=0.69-1.28)。相比之下，ApoE ɛ4 等位基因与 a-MCI 显著相关 (OR=1.75；95% CI=1.28-2.41)，但与 na-MCI 不相关 (OR=1.17；95% CI=0.69-2.00)。CHD 与现患 na-MCI 相关但与 a-MCI 不相关表明，CHD 和 na-MCI 可能具有相似的潜在病因。
