轻度认知障碍亚型中的血管危险因素。来自ReGAl项目的研究结果。
Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project.
作者信息
Mariani E, Monastero R, Ercolani S, Mangialasche F, Caputo M, Feliziani F T, Vitale D F, Senin U, Mecocci P
机构信息
Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
出版信息
Dement Geriatr Cogn Disord. 2007;24(6):448-56. doi: 10.1159/000110653. Epub 2007 Nov 1.
BACKGROUND AND AIM
To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study.
METHODS
Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.
RESULTS
snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.
CONCLUSION
Our findings suggest that snmMCI may be considered a vascular cognitive disorder.
背景与目的
在一项多中心、基于临床的横断面研究中，调查血管危险因素在轻度认知障碍（MCI）不同亚型中的作用。
方法
本研究纳入了207例MCI患者：33例为单一非记忆型MCI（snmMCI），42例为多领域遗忘型MCI（mdMCI-a），132例为遗忘型MCI（aMCI）。评估了几种临床血管危险因素和磁共振成像（MRI）脑损伤情况。
结果
与aMCI相比，snmMCI的缺血性心脏病和短暂性脑缺血发作（TIA）/中风发生率更高，Hachinski缺血评分更高，MRI上白质病变频率更高。mdMCI-a患者的临床特征与aMCI相似，只是TIA/中风病史的发生率更高。
结论
我们的研究结果表明，snmMCI可能被视为一种血管性认知障碍。
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