Lee Kyungwon, Kim Mi-Na, Choi Tae Yeal, Cho Soung-Eun, Lee Seungok, Whang Dong Hee, Yong Dongeun, Chong Yunsop, Woodford Neil, Livermore David M
Yonsei University College of Medicine, Seoul, South Korea.
Int J Antimicrob Agents. 2009 Jun;33(6):520-4. doi: 10.1016/j.ijantimicag.2008.10.009. Epub 2008 Dec 16.
Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-beta-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed bla(OXA) carbapenemase genes. Among the latter, 47 had bla(OXA-23)-like genes and 56 had upregulated bla(OXA-51)-like variants, including bla(OXA-66), (-83), (-109) and (-115); bla(OXA-115) was a novel variant, detected in two isolates. bla(OXA-72) (bla(OXA-40)-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both bla(VIM-2)-like and bla(OXA-58) genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.
耐碳青霉烯类不动杆菌在全球范围内的报告日益增多，包括在韩国。我们对2005年全国医院调查中收集的144株代表性菌株进行了检测。仅19.4%的菌株检测到金属β-内酰胺酶，其中没有鲍曼不动杆菌，而74.3%的菌株（大多数为鲍曼不动杆菌）表达bla(OXA)碳青霉烯酶基因。在后者中，47株具有bla(OXA - 23)样基因，56株具有上调的bla(OXA - 51)样变体，包括bla(OXA - 66)、(- 83)、(- 109)和(- 115)；bla(OXA - 115)是一种新变体，在两株菌株中检测到。bla(OXA - 72)（bla(OXA - 40)样）仅在一株拜氏不动杆菌中检测到，而三株醋酸钙不动杆菌同时具有bla(VIM - 2)样和bla(OXA - 58)基因。脉冲场凝胶电泳（PFGE）表明，携带OXA碳青霉烯酶的鲍曼不动杆菌克隆在医院内部和医院之间传播。总之，韩国近期耐亚胺培南不动杆菌的增加主要归因于OXA型碳青霉烯酶。
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