肿瘤抑制多肽的Rassf家族。
Rassf family of tumor suppressor polypeptides.
作者信息
Avruch Joseph, Xavier Ramnik, Bardeesy Nabeel, Zhang Xian-Feng, Praskova Maria, Zhou Dawang, Xia Fan
机构信息
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
出版信息
J Biol Chem. 2009 Apr 24;284(17):11001-5. doi: 10.1074/jbc.R800073200. Epub 2008 Dec 17.
Abstract
The Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and pro-apoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.
摘要
Rassf1 - 6多肽各自包含一个Ras/Rap结合结构域，至少在体外或过表达时，该结构域能够与几种结合了GTP的Ras样GTP酶结合。Ras/Rap结合结构域之后是SARAH结构域，其介导Rassf与Mst1/2蛋白激酶的异源二聚化。Rassf1A无疑是一种肿瘤抑制因子，并且所有Rassf蛋白都表现出肿瘤抑制因子的特性，在许多人类癌症中表现出表达的表观遗传沉默，当在肿瘤细胞系中重新表达时具有促凋亡和/或抗增殖作用。在此，我们综述Rassf多肽与Ras样GTP酶和Mst1/2激酶的结合及其在Rassf功能中的作用。
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