Marsh R L, Smith-Vaughan H, Beissbarth J, Hare K, Kennedy M, Wigger C, Mellon G, Stubbs E, Gadil J R, Pettit A, Mackenzie G, Tipakalippa P, Morris P S, Leach A J
Menzies School of Health Research, Darwin, Northern Territory, Australia.
Vaccine. 2007 Mar 22;25(13):2434-6. doi: 10.1016/j.vaccine.2006.09.016. Epub 2006 Sep 18.
Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneumococcal immunisation for Aboriginal infants in 2001, 16F has become the predominant established serotype in carriage and otitis media in young Aboriginal children. BOX typing and multi-locus sequence typing revealed a diverse population of serotype 16F strains, and evidence of potential capsule switching from a vaccine serotype 4 to a serotype 16F.
偏远社区的澳大利亚原住民幼儿肺炎球菌携带率和中耳炎发病率非常高。在引入7价肺炎球菌结合疫苗（7vPCV，沛儿）之前，血清型16F是在鼻拭子和耳拭子中发现的一种重要血清型。自2001年开始对原住民婴儿进行肺炎球菌免疫接种以来，16F已成为原住民幼儿携带和中耳炎中主要的既定血清型。BOX分型和多位点序列分型显示血清型16F菌株群体多样，并有从疫苗血清型4潜在转换为血清型16F的证据。
