Zhuang H, Cao X Y, Liu C B, Wang G M
Department of Epidemiology, School of Public Health, Beijing Medical University, China.
Gastroenterol Jpn. 1991 Jul;26 Suppl 3:135-8. doi: 10.1007/BF02779283.
A total of 9 hepatitis E epidemics have been documented in China since 1982. Five of them were waterborne and four foodborne, and they occurred in 6 of 30 provinces or autonomous regions in the country. The disease most frequently affects young adults, with fewer cases in children and the elderly. A relative male excess of cases has been observed. However, the fatality rate in female patients with hepatitis E is significantly higher than in males. The disease has a distinctive autumn seasonality in endemic areas. A peak of fecal excretion of hepatitis E virus is found at the late incubation period and early acute phase. The incubation period of the disease ranges from 15 to 75 days, with a mean of 36 days. A randomized double-blind and controlled study showed that human immune serum globulin had no prophylactic effects on hepatitis E.
自1982年以来，中国共记录了9次戊型肝炎疫情。其中5次是经水传播，4次是经食物传播，疫情发生在全国30个省或自治区中的6个。该疾病最常影响青壮年，儿童和老年人病例较少。已观察到病例中男性相对较多。然而，戊型肝炎女性患者的病死率明显高于男性。在流行地区，该疾病具有明显的秋季季节性。戊型肝炎病毒粪便排泄高峰出现在潜伏期晚期和急性期早期。该疾病的潜伏期为15至75天，平均为36天。一项随机双盲对照研究表明，人免疫球蛋白对戊型肝炎没有预防作用。
