Medical Students Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
World J Pediatr. 2010 Nov;6(4):357-60. doi: 10.1007/s12519-010-0236-6. Epub 2010 Nov 16.
Despite long standing iodine supplementation in Iran the prevalence of goiter remains high in some areas. In the present study we investigated the possible role of thiocyanate as a goitrogen in the etiology of goiter in Isfahan, Iran.
A total of 2331 (6-13 year old) school children were selected by multistage random sampling. Thyroid size was estimated in each child by inspection and palpation. Urinary iodine concentration (UIC) and urinary thiocyanate (USCN) were measured.
Overall, 32.9% of the 2331 students had goiter. The median UIC was 195.5 μg/L. The mean ± SD of USCN in goitrous and nongoitrous subjects was 0.42 ± 0.28 mg/dL and 0.41 ± 0.32 mg/dL, respectively (P=0.86). USCN level in goitrous and nongoitrous boys was 0.41 ± 0.32 mg/dL and 0.43 ± 0.37 mg/dL, respectively (P=0.67). USCN level in goitrous and nongoitrous girls was 0.43 ± 0.26 mg/dL and 0.40 ± 0.28 mg/dL, respectively (P=0.43).
Thiocyanate overload does not play a role in high prevalence of goiter in the studied population. We suggest the role of other goitrogenic factors should be investigated in this region.
尽管伊朗长期以来一直补充碘，但在某些地区甲状腺肿的患病率仍然很高。在本研究中，我们研究了硫氰酸盐作为致甲状腺肿原在伊朗伊斯法罕甲状腺肿发病机制中的可能作用。
通过多阶段随机抽样选择了 2331 名（6-13 岁）在校儿童。通过视诊和触诊评估每个儿童的甲状腺大小。测量尿碘浓度（UIC）和尿硫氰酸盐（USCN）。
总体而言，2331 名学生中有 32.9%患有甲状腺肿。UIC 的中位数为 195.5μg/L。甲状腺肿和非甲状腺肿患者的 USCN 平均值±SD 分别为 0.42±0.28mg/dL 和 0.41±0.32mg/dL（P=0.86）。甲状腺肿和非甲状腺肿男孩的 USCN 水平分别为 0.41±0.32mg/dL 和 0.43±0.37mg/dL（P=0.67）。甲状腺肿和非甲状腺肿女孩的 USCN 水平分别为 0.43±0.26mg/dL 和 0.40±0.28mg/dL（P=0.43）。
硫氰酸盐过载在研究人群中高甲状腺肿患病率中不起作用。我们建议在该地区应研究其他致甲状腺肿因素的作用。
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