Grivas T B, Psarakis S A, Kaspiris Alpha, Liapi G
Department of Trauma and Orthopaedics, Thriasio General Hospital-NHS, G. Gennimata Avenue, Magoula 19600 Attica, Greece.
Hand (N Y). 2009 Jun;4(2):173-6. doi: 10.1007/s11552-008-9157-4. Epub 2008 Dec 18.
Giant lipomas of the thenar are rare tumours of the adipose tissue of the hand, with a benign prognosis. Apart from the cosmetic problems they may cause, their most frequent complications include a compromise in functionality and pressure upon the nerves, mainly on the radial nerve. The first step in their management is their differential diagnosis from well-differentiated liposarcomas (WDLPS), as they require a different therapeutic approach. This step is completed with the aid of MRIs, biopsies and modern immunohistochemical methods, which offer high specificity and sensitivity. Our paper presents a case of giant lipoma of the thenar, with a review of the relevant literature, focusing on the disease's molecular genetics, which is a very important field of research today.
大鱼际肌巨大脂肪瘤是手部脂肪组织的罕见肿瘤，预后良好。除了可能引起的美容问题外，其最常见的并发症包括功能受损以及对神经，主要是桡神经的压迫。治疗的第一步是将其与高分化脂肪肉瘤（WDLPS）进行鉴别诊断，因为它们需要不同的治疗方法。这一步借助磁共振成像（MRI）、活检和现代免疫组化方法得以完成，这些方法具有高特异性和敏感性。我们的论文展示了一例大鱼际肌巨大脂肪瘤病例，并对相关文献进行了综述，重点关注该疾病的分子遗传学，这是当今一个非常重要的研究领域。
