[氧杂三唑鎓-5-醇盐衍生物的降压作用]
[Hypotensive effect of oxatriazolium-5-olate derivative].
作者信息
Artem'eva M M, Postnikov A B, Akinfrieva O V, Daliger I L, Shevelev S A, Medvedev O S, Medvedeva N A
出版信息
Eksp Klin Farmakol. 2008 Sep-Oct;71(5):25-7.
PMID:19093367
Abstract
Intravenous administration of azasidnon-6 (oxatriazolium-5-olate derivative) induces prolonged dose-dependent decrease in arterial blood pressure in awake Wistar and SHR rats. Hypotensive effects of azasidnon-6 in SHR rats is significantly higher during inhibition of endogenous NO synthesis.
摘要
静脉注射氮杂环壬烷-6（氧杂三唑鎓-5-醇盐衍生物）可使清醒的Wistar大鼠和SHR大鼠的动脉血压出现剂量依赖性的长时间降低。在抑制内源性一氧化氮合成期间，氮杂环壬烷-6对SHR大鼠的降压作用显著增强。
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