Galagan M E, Oranovskaia E V, Mordvintsev P I, Medvedev O S, Vanin A F
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1988;11(2):75-80.
Changes in arterial pressure evoked by dinitrosyl iron complexes (DNIC) were studied in conscious normotensive (Wistar) and spontaneously hypertensive (SHR) rats. Doses from 1 to 10 mcM/kg of DNIC evoked dose-dependent decrease in blood pressure for two hours. SHR rats were more sensitive to the effect of the drug than normotensive Wistar rats. Long-lasting effects of the drug depended on the NO-stores, which were DNIC with paired RS-(-)groups of proteins. These complexes measured with EPR method were formed as a result of Fe(NO)2 groups transfer from injected low molecular weight DNIC to protein RS-(-)groups.
在清醒的正常血压（Wistar）大鼠和自发性高血压（SHR）大鼠中研究了二亚硝基铁配合物（DNIC）引起的动脉血压变化。剂量为1至10 μM/kg的DNIC可使血压在两小时内呈剂量依赖性下降。SHR大鼠比正常血压的Wistar大鼠对该药物的作用更敏感。该药物的长期作用取决于NO储备，即具有成对RS-（-）蛋白基团的DNIC。通过电子顺磁共振（EPR）方法测量的这些配合物是由于Fe（NO）2基团从注射的低分子量DNIC转移到蛋白质RS-（-）基团而形成的。
