Dursun Semiha, Demirci Esra, Kilic Eser, Ozmen Sevgi
Departments of Child and Adolescent Psychiatry, Kayseri, Turkey.
Departments of Biochemistry, Erciyes University, Kayseri, Turkey.
Clin Psychopharmacol Neurosci. 2021 Feb 28;19(1):145-154. doi: 10.9758/cpn.2021.19.1.145.
Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental and biological factors are considered to play a role in the etiology of ADHD by mutually interacting. Recent studies have emphasized that inflammation may be present in the etiology of ADHD. This study aims to investigate the possible role of visfatin, IL-6, IL-1b and TNF-α molecules in the etiology of ADHD.
The study included 60 patients and 20 healthy controls between the ages of 6-18. Serum visfatin, IL-6, IL-1b and TNF-α levels were evaluated with enzyme-linked immunosorbent assay (ELISA) kits at a biochemistry laboratory.
The study showed no statistically significant difference between children with ADHD and healthy controls in terms of visfatin, IL-6, IL-1b and TNF-α levels. When ADHD subgroups (combined and predominantly inattentive types) and the control group were compared in terms of visfatin, IL-6, IL-1b and TNF-α levels, no statistically significant difference was recorded.
Data on the relationship between ADHD and IL-6, IL-1b and TNF-α in this study are in compliance with the literature. However, no study was found on visfatin in ADHD. This study is the first one evaluating the ADHD-Visfatin relationship.
注意力缺陷多动障碍（ADHD）病因复杂，遗传、环境和生物因素被认为通过相互作用在ADHD病因中发挥作用。最近的研究强调炎症可能存在于ADHD的病因中。本研究旨在探讨内脂素、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）分子在ADHD病因中的可能作用。
该研究纳入了60例6至18岁的患者和20名健康对照者。在生物化学实验室使用酶联免疫吸附测定（ELISA）试剂盒评估血清内脂素、IL-6、IL-1β和TNF-α水平。
研究表明，ADHD患儿与健康对照者在内脂素、IL-6、IL-1β和TNF-α水平方面无统计学显著差异。当比较ADHD亚组（混合型和主要为注意力不集中型）与对照组在内脂素、IL-6、IL-1β和TNF-α水平时，未记录到统计学显著差异。
本研究中关于ADHD与IL-6、IL-1β和TNF-α之间关系的数据与文献一致。然而，尚未发现有关ADHD与内脂素关系的研究。本研究是第一项评估ADHD与内脂素关系的研究。
