口服脊髓灰质炎疫苗及其在印度根除脊髓灰质炎中的作用。

Oral polio vaccines and their role in polio eradication in India.

作者信息

Paul Yash

机构信息

Maharaja Agrasen Hospital, Vidhyadhar Nagar, A-D-7 Devi Marg, Bani Park, Jaipur-302016, India.

出版信息

Expert Rev Vaccines. 2009 Jan;8(1):35-41. doi: 10.1586/14760584.8.1.35.

DOI:10.1586/14760584.8.1.35

PMID:19093771

Abstract

Although the oral polio vaccine has reduced the incidence of polio in India, the current polio scenario indicates that oral polio vaccine cannot eradicate polio from Uttar Pradesh and Bihar, two states that have approximately 32% of the total Indian population and report more than 96% of polio cases that occur in India. Poor response to oral polio vaccine by some children from these two states could be due to genetic factors. Thus, for polio eradication in India, inactivated polio vaccine is needed.

摘要

尽管口服脊髓灰质炎疫苗降低了印度脊髓灰质炎的发病率，但当前的脊髓灰质炎情况表明，口服脊髓灰质炎疫苗无法在北方邦和比哈尔邦根除脊髓灰质炎，这两个邦的人口约占印度总人口的32%，报告的脊髓灰质炎病例占印度发生病例的96%以上。来自这两个邦的一些儿童对口服脊髓灰质炎疫苗反应不佳可能是由于遗传因素。因此，为在印度根除脊髓灰质炎，需要使用灭活脊髓灰质炎疫苗。