Mancuso Michael R, Kuhnert Frank, Kuo Calvin J
Stanford University School of Medicine. Division of Hematology, Stanford, CA.
Lymphat Res Biol. 2008;6(3-4):173-80. doi: 10.1089/lrb.2008.1014.
The vasculature of the central nervous system (CNS) is highly specialized with a blood-brain-barrier, reciprocal neuroepithelial-endothelial cell interactions and extensive pericyte coverage. Developmentally, numerous important signaling pathways participate in CNS angiogenesis to orchestrate the precise timing and spatial arrangement of the complex CNS vascular network. From a therapeutic standpoint, the CNS vasculature has attracted increased attention since many human ailments, such as stroke, retinopathy, cancer and autoimmune disease are intimately associated with the biology of CNS blood vessels. This review focuses on growth factor pathways that have been shown to be important in developmental CNS vascularization through studies of mouse genetic models and human diseases.
中枢神经系统（CNS）的脉管系统高度特化，具有血脑屏障、神经上皮细胞与内皮细胞的相互作用以及广泛的周细胞覆盖。在发育过程中，众多重要的信号通路参与中枢神经系统血管生成，以协调复杂的中枢神经系统血管网络的精确时间和空间排列。从治疗角度来看，中枢神经系统脉管系统已引起越来越多的关注，因为许多人类疾病，如中风、视网膜病变、癌症和自身免疫性疾病都与中枢神经系统血管生物学密切相关。本综述重点关注通过小鼠遗传模型和人类疾病研究已证明在中枢神经系统发育性血管生成中起重要作用的生长因子通路。
