Dhindsa Sandeep, Upadhyay Manish, Viswanathan Prabhakar, Howard Susan, Chaudhuri Ajay, Dandona Paresh
Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Buffalo, New York Kaleida Health, Buffalo, NY, USA.
Endocr Pract. 2008 Nov;14(8):1000-5. doi: 10.4158/EP.14.8.1000.
To determine whether prostate-specific antigen (PSA) concentrations in type 2 diabetic men with hypogonadotrophic hypogonadism are lower than those in eugonadal men with type 2 diabetes and whether PSA concentrations are related to plasma testosterone concentrations.
In this cross-sectional study, we measured serum total testosterone, sex hormone-binding globulin, free testosterone, PSA, hematocrit, and hemoglobin A1c in consecutive type 2 diabetic men who presented to 2 endocrinology referral centers between January 2006 and January 2007. We collected other clinical and demographic data including age, height, weight, and ethnicity.
Of 400 eligible patients, 280 men met inclusion criteria. Plasma PSA concentrations were lower in type 2 diabetic men with low free testosterone concentrations than in those with normal free testosterone concentrations (0.89 +/- 0.07 ng/mL vs 1.10 +/- 0.08 ng/mL, [corrected] P = .011). PSA concentrations were positively related to age (r = 0.34, P<.001), total testosterone (r = 0.29, P<.001), free testosterone (r = 0.17, P = .02), and sex hormone-binding globulin (r = 0.22, P<.001) and negatively related to body mass index (r = -0.28, P<.001). In stepwise backward regression analysis, PSA concentration was predicted by age (P<.001) and free testosterone (P<.001), but not by body mass index or sex hormone-binding globulin.
Plasma PSA concentrations are lower in type 2 diabetic men with hypogonadism than in eugonadal men with type 2 diabetes, and plasma PSA is related to age, plasma total testosterone concentrations, and free testosterone concentrations in patients with type 2 diabetes.
确定患有低促性腺激素性性腺功能减退的2型糖尿病男性的前列腺特异性抗原（PSA）浓度是否低于性腺功能正常的2型糖尿病男性，以及PSA浓度是否与血浆睾酮浓度相关。
在这项横断面研究中，我们对2006年1月至2007年1月期间到2个内分泌转诊中心就诊的连续2型糖尿病男性测量了血清总睾酮、性激素结合球蛋白、游离睾酮、PSA、血细胞比容和糖化血红蛋白A1c。我们收集了其他临床和人口统计学数据，包括年龄、身高、体重和种族。
在400名符合条件的患者中，280名男性符合纳入标准。游离睾酮浓度低的2型糖尿病男性的血浆PSA浓度低于游离睾酮浓度正常的男性（0.89±0.07 ng/mL对1.10±0.08 ng/mL，[校正后]P = 0.011）。PSA浓度与年龄（r = 0.34，P<0.001）、总睾酮（r = 0.29，P<0.001）、游离睾酮（r = 0.17，P = 0.02）和性激素结合球蛋白（r = 0.22，P<0.001）呈正相关，与体重指数呈负相关（r = -0.28，P<0.001）。在逐步向后回归分析中，PSA浓度由年龄（P<0.001）和游离睾酮（P<0.001）预测，但不由体重指数或性激素结合球蛋白预测。
性腺功能减退的2型糖尿病男性的血浆PSA浓度低于性腺功能正常的2型糖尿病男性，并且血浆PSA与2型糖尿病患者的年龄、血浆总睾酮浓度和游离睾酮浓度相关。
