Al-Asadi Jasim N, Al-Naama Lamia M, Abdul-Kareem Muhannad M, Mashkoor Fawzi C
Department of Community Medicine, College of Medicine, Basrah University, Basrah, Iraq.
Department of Biochemistry, College of Medicine, Basrah University, Basrah, Iraq.
Niger Postgrad Med J. 2017 Oct-Dec;24(4):240-244. doi: 10.4103/npmj.npmj_174_17.
The aim of this study was to determine the effect of type 2 diabetes mellitus (DM) on the serum level of prostate-specific antigen (PSA) in men in Basrah, Iraq.
A case-control study was done including 70 confirmed type 2 diabetic patients and 70 non-diabetic persons. Data about age and family history of diabetes were collected. For diabetic patients, data related to disease history were also enquired about. Weight and height were measured and body mass index (BMI) was calculated. Blood examination was done to estimate fasting plasma glucose and PSA.
The mean ages of diabetic and non-diabetic patients were 55.2 ± 10.5 and 55.9 ± 10.9 years, respectively. The mean total serum PSA was significantly lower among diabetic than non-diabetic men (1.97 ± 1.05 ng/ml vs. 2.60 ± 1.22 ng/ml, respectively, P = 0.001). The multivariate linear regression analysis showed that age, DM and BMI were independent predictors of serum PSA variation. Age was significantly related to PSA in non-diabetics, but not in diabetic patients.
Serum PSA level is significantly lower and less age dependent in type 2 diabetic patients than in non-diabetics. Therefore, DM should be considered in setting of PSA threshold when screening for prostate cancer.
本研究旨在确定2型糖尿病（DM）对伊拉克巴士拉男性血清前列腺特异性抗原（PSA）水平的影响。
开展了一项病例对照研究，纳入70例确诊的2型糖尿病患者和70例非糖尿病患者。收集了有关年龄和糖尿病家族史的数据。对于糖尿病患者，还询问了与疾病史相关的数据。测量体重和身高并计算体重指数（BMI）。进行血液检查以评估空腹血糖和PSA。
糖尿病患者和非糖尿病患者的平均年龄分别为55.2±10.5岁和55.9±10.9岁。糖尿病男性的平均总血清PSA显著低于非糖尿病男性（分别为1.97±1.05 ng/ml和2.60±1.22 ng/ml，P = 0.001）。多变量线性回归分析表明，年龄、DM和BMI是血清PSA变化的独立预测因素。年龄与非糖尿病患者的PSA显著相关，但与糖尿病患者无关。
2型糖尿病患者的血清PSA水平显著低于非糖尿病患者，且对年龄的依赖性较小。因此，在前列腺癌筛查中设定PSA阈值时应考虑DM因素。
