Ainahi Abdelhakim, Brakat Abdelhamid, Wakrim Lahcen, Mohammadi Hicham, ElMdaghri Naima, Ezzikouri Sayeh
Hormonology and Tumor Markers Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Human Molecular Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Curr Diabetes Rev. 2018;14(3):286-290. doi: 10.2174/1573399813666170117113519.
Recent studies have shown an inverse relationship between diabetes and prostate- specific antigen (PSA) levels.
This study aimed to evaluate the PSA levels in the serum of diabetic and non-diabetic Moroccan males.
In a cross-sectional study, four hundred and seventy diabetic and 869 non-diabetic males were screened from January 2015 to April 2016 at Pasteur institute of Morocco. Hemoglobin A1c and Fasting Blood Glucose were measured using high performance liquid chromatography and dry chemistry, respectively. We used a chemiluminescent microparticle immunoassay technology to evaluate the levels of Serum PSA and testosterone.
Overall, the PSA levels revealed no significant difference between diabetic and non-diabetic males (1.31 ± 0.04ng/mL vs.1.36 ± 0.03ng/mL, p = 0.380, respectively). The PSA levels increased with age both in non-diabetics and diabetics. Moreover, in diabetic subjects, the PSA levels were less age dependent (p =0.002) than in non-diabetic (p < 0.0001). The stratified analysis showed that the PSA was significantly lower in diabetic than in non-diabetic subjects aged between 50-59 years (p= 0.0004). Furthermore, no significant testosterone concentrations were observed in the subjects with or without diabetes (p= 0.904).
Our results show that the PSA levels are age-dependant in diabetic and non-diabetic males but the PSA levels are affected by diabetes status only in the group aged between 50-59 years.
近期研究表明糖尿病与前列腺特异性抗原（PSA）水平之间存在负相关关系。
本研究旨在评估摩洛哥糖尿病男性和非糖尿病男性血清中的PSA水平。
在一项横断面研究中，于2015年1月至2016年4月在摩洛哥巴斯德研究所对470名糖尿病男性和869名非糖尿病男性进行了筛查。分别使用高效液相色谱法和干化学法测量糖化血红蛋白和空腹血糖。我们采用化学发光微粒子免疫分析技术评估血清PSA和睾酮水平。
总体而言，糖尿病男性和非糖尿病男性的PSA水平无显著差异（分别为1.31±0.04ng/mL和1.36±0.03ng/mL，p = 0.380）。非糖尿病患者和糖尿病患者的PSA水平均随年龄增长而升高。此外，在糖尿病患者中，PSA水平的年龄依赖性（p = 0.002）低于非糖尿病患者（p < 0.0001）。分层分析显示，50 - 59岁的糖尿病患者的PSA水平显著低于非糖尿病患者（p = 0.0004）。此外，无论是否患有糖尿病，患者的睾酮浓度均无显著差异（p = 0.904）。
我们的结果表明，糖尿病男性和非糖尿病男性的PSA水平均与年龄相关，但仅在50 - 59岁年龄段的人群中，糖尿病状态会影响PSA水平。
