Beck-Nielsen Signe Sparre, Brock-Jacobsen Bendt, Gram Jeppe, Brixen Kim, Jensen Tina Kold
Department of Pediatrics, Hospital of Southwest Denmark, Esbjerg, Denmark.
Eur J Endocrinol. 2009 Mar;160(3):491-7. doi: 10.1530/EJE-08-0818. Epub 2008 Dec 18.
To estimate the incidence of nutritional rickets and the incidence and prevalence of hereditary rickets.
Population-based retrospective cohort study based on a review of medical records.
Patients aged 0-14.9 years referred to or discharged from hospitals in southern Denmark from 1985 to 2005 with a diagnosis of rickets were identified by register search, and their medical records were retrieved. Patients fulfilling the diagnostic criteria of primary rickets were included.
We identified 112 patients with nutritional rickets of whom 74% were immigrants. From 1995 to 2005, the average incidence of nutritional rickets in children aged 0-14.9 and 0-2.9 years was 2.9 and 5.8 per 100,000 per year respectively. Among immigrant children born in Denmark, the average incidence was 60 (0-14.9 years) per 100,000 per year. Ethnic Danish children were only diagnosed in early childhood and the average incidence in the age group 0-2.9 years declined from 5.0 to 2.0 per 100,000 per year during 1985-1994 to 1995-2005. Sixteen cases of hereditary rickets were diagnosed during the study period giving an average incidence of 4.3 per 100,000 (0-0.9 years) per year. The prevalence of hypophosphatemic rickets and vitamin D-dependent rickets type 1 was 4.8 and 0.4 per 100,000 (0-14.9 years) respectively.
Nutritional rickets is rare in southern Denmark and largely restricted to immigrants, but the incidence among ethnic Danish children was unexpectedly high. Hereditary rickets is the most common cause of rickets in ethnic Danish children, but nutritional rickets is most frequent among all young children.
评估营养性佝偻病的发病率以及遗传性佝偻病的发病率和患病率。
基于病历回顾的人群回顾性队列研究。
通过登记搜索确定1985年至2005年期间转诊至丹麦南部医院或从丹麦南部医院出院、年龄在0至14.9岁且诊断为佝偻病的患者，并检索其病历。纳入符合原发性佝偻病诊断标准的患者。
我们确定了112例营养性佝偻病患者，其中74%为移民。1995年至2005年期间，0至14.9岁儿童和0至2.9岁儿童营养性佝偻病的年平均发病率分别为每10万人2.9例和5.8例。在丹麦出生的移民儿童中，年平均发病率为每10万人60例（0至14.9岁）。丹麦族裔儿童仅在幼儿期被诊断出，在1985 - 1994年至1995 - 2005年期间，0至2.9岁年龄组的年平均发病率从每10万人5.0例降至2.0例。研究期间诊断出16例遗传性佝偻病，年平均发病率为每10万人4.3例（0至0.9岁）。低磷血症性佝偻病和1型维生素D依赖性佝偻病的患病率分别为每10万人4.8例和0.4例（0至14.9岁）。
营养性佝偻病在丹麦南部很少见，主要限于移民，但丹麦族裔儿童中的发病率意外地高。遗传性佝偻病是丹麦族裔儿童佝偻病最常见的病因，但在所有幼儿中营养性佝偻病最为常见。
