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抗抑郁药物使用中的种族和民族差异。

Racial and ethnic disparities in antidepressant drug use.

作者信息

Chen Jie, Rizzo John A

机构信息

Department of Political Science, Economics and Philosophy, College of Staten Island/CUNY, 2800 Victory Blvd., Room 2N-229 Staten Island, NY 10314, USA.

出版信息

J Ment Health Policy Econ. 2008 Dec;11(4):155-65.

Abstract

BACKGROUND

Little is known about racial and ethnic disparities in health care utilization, expenditures and drug choice in the antidepressant market.

AIMS

This study investigates factors associated with the racial and ethnic disparities in antidepressant drug use. We seek to determine the extent to which disparities reflect differences in observable population characteristics versus heterogeneity across racial and ethnic groups. Among the population characteristics, we are interested in identifying which factors are most important in accounting for racial and ethnic disparities in antidepressant drug use.

METHODS

Using Medical Expenditure Panel Survey (MEPS) data from 1996-2003, we have an available sample of 10,416 Caucasian, 1,089 African American and 1,539 Hispanic antidepressant drug users aged 18 to 64 years. We estimate individual out-of-pocket payments, total prescription drug expenditures, drug utilization, the probability of taking generic versus brand name antidepressants, and the share of drugs that are older types of antidepressants (e.g., TCAs and MAOIs) for these individuals during a calendar year. Blinder-Oaxaca decomposition techniques are employed to determine the extent to which disparities reflect differences in observable population characteristics versus unobserved heterogeneity across racial and ethnic groups.

RESULTS

Caucasians have the highest antidepressant drug expenditures and utilization. African-Americans have the lowest drug expenditures and Hispanics have the lowest drug utilization. Relative to Caucasians and Hispanics, African-Americans are more likely to purchase generics and use a higher share of older drugs (e.g., TCAs and MAOIs). Differences in observable characteristics explain most of the racial/ethnic differences in these outcomes, with the exception of drug utilization. Differences in health insurance and education levels are particularly important factors in explaining disparities. In contrast, differences in drug utilization largely reflect unobserved heterogeneity across these population groups.

CONCLUSIONS

Substantive racial and ethnic disparities exist in all dimensions of antidepressant drug use examined. Observable population characteristics account for most of the differences in the expenditures, with health insurance and education key factors driving differences in spending. Observable characteristics are also important in explaining racial and ethnic disparities in the probability of purchasing generics and new vs old antidepressant drugs used. Differences in total utilization are not well-explained by observable characteristics, and may reflect unobserved heterogeneity such as unobserved physician-patient relationships, mistrust, and cultural factors.

IMPLICATIONS FOR POLICY

Reducing differences in observable characteristics such as health insurance and education will mitigate racial and ethnic disparities in expenditures on antidepressant drug use and in the types of antidepressant used (e.g., generics vs. brands; new vs old). But these factors will have less influence in reducing racial and ethnic disparities in overall antidepressant drug utilization. To limit differences in overall antidepressant drug use, policymakers must take into account cultural factors and other sources of heterogeneity.

摘要

背景

关于医疗保健利用、支出以及抗抑郁药市场中药物选择方面的种族和民族差异,我们了解得很少。

目的

本研究调查与抗抑郁药使用方面的种族和民族差异相关的因素。我们试图确定这些差异在多大程度上反映了可观察到的人群特征差异,而非不同种族和民族群体之间的异质性。在人群特征中,我们有兴趣确定哪些因素在解释抗抑郁药使用方面的种族和民族差异时最为重要。

方法

利用1996 - 2003年医疗支出面板调查(MEPS)的数据,我们获得了一个包含10416名年龄在18至64岁之间的白人、1089名非裔美国人和1539名西班牙裔抗抑郁药使用者的样本。我们估算了这些个体在一个日历年内的自付费用、处方药总支出、药物使用情况、服用通用名抗抑郁药与品牌名抗抑郁药的概率,以及使用较老式抗抑郁药(如三环类抗抑郁药和单胺氧化酶抑制剂)的药物占比。采用布林德 - 奥瓦卡分解技术来确定这些差异在多大程度上反映了可观察到的人群特征差异,而非不同种族和民族群体之间未观察到的异质性。

结果

白人的抗抑郁药支出和使用量最高。非裔美国人的药物支出最低,西班牙裔的药物使用量最低。相对于白人和西班牙裔,非裔美国人更有可能购买通用名药物,且使用较老式药物(如三环类抗抑郁药和单胺氧化酶抑制剂)的比例更高。可观察到的特征差异解释了这些结果中大部分的种族/民族差异,但药物使用情况除外。医疗保险和教育水平的差异是解释这些差异的特别重要因素。相比之下,药物使用情况的差异在很大程度上反映了这些人群组之间未观察到的异质性。

结论

在所研究的抗抑郁药使用的各个方面都存在显著的种族和民族差异。可观察到的人群特征解释了支出方面的大部分差异,医疗保险和教育是导致支出差异的关键因素。可观察到的特征在解释购买通用名药物的概率以及使用新老抗抑郁药方面的种族和民族差异时也很重要。总使用量的差异无法通过可观察到的特征得到很好的解释,可能反映了未观察到的异质性,如未观察到的医患关系、不信任和文化因素。

对政策的启示

减少医疗保险和教育等可观察到的特征差异,将减轻抗抑郁药使用支出以及所使用抗抑郁药类型(如通用名药与品牌药;新药与老药)方面的种族和民族差异。但这些因素在减少总体抗抑郁药使用方面的种族和民族差异方面影响较小。为了限制总体抗抑郁药使用的差异,政策制定者必须考虑文化因素和其他异质性来源。

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