Duprez D, Baele G, De Buyzere M, Vandenbroecke P, Clement D L
Department of Cardiology-Angiology, University Hospital, Ghent, Belgium.
Eur Heart J. 1991 Jul;12(7):800-2.
A 20-min venous occlusion and a desmopressin acetate (DDAVP, 0.4 microgram.Kg-1, 15 min) infusion test have been compared to evaluate fibrinolytic capacity in proven coronary artery disease. Basal values of plasma tissue plasminogen activator (t-PA) activity and antigen and of t-PA inhibitor (PAI) were normally distributed in this patient group. However, after both stimuli, highly significant (P less than 0.005) increases of t-PA antigen and activity have been observed. Renormalization of t-PA levels after DDAVP infusion occurred more rapidly for antigen (120 min) than for activity concentrations (greater than 240 min). A DDAVP infusion test seems more appropriate for evaluation of the fibrinolytic capacity as the induced decrease in PAI level was significant (P less than 0.005) and lasted for at least 240 min, while it was not significant for the venous occlusion test.
为评估经证实患有冠状动脉疾病患者的纤溶能力，对20分钟静脉阻塞试验和醋酸去氨加压素（DDAVP，0.4微克·千克⁻¹，15分钟）输注试验进行了比较。该患者组血浆组织型纤溶酶原激活物（t-PA）活性、抗原以及t-PA抑制剂（PAI）的基础值呈正态分布。然而，在两种刺激后，均观察到t-PA抗原和活性显著升高（P<0.005）。DDAVP输注后t-PA水平恢复正常，抗原（120分钟）比活性浓度（>240分钟）更快。DDAVP输注试验似乎更适合评估纤溶能力，因为诱导的PAI水平降低显著（P<0.005）且持续至少240分钟，而静脉阻塞试验则不显著。
