Division of Engineering, Brown University, Providence, RI 02912, USA.
Biomed Microdevices. 2010 Aug;12(4):575-87. doi: 10.1007/s10544-008-9264-6.
Future biomaterials must simultaneously enhance tissue regeneration while minimizing immune responses and inhibiting infection. While the field of tissue engineering has promised to develop materials that can promote tissue regeneration for the entire body, such promises have not become reality. However, tissue engineering has experienced great progress due to the recent emergence of nanotechnology. Specifically, it has now been well established that increased tissue regeneration can be achieved on almost any surface by employing novel nano-textured surface features. Numerous studies have reported that nanotechnology accelerates various regenerative therapies, such as those for the bone, vascular, heart, cartilage, bladder and brain tissue. Various nano-structured polymers and metals (alloys) have been investigated for their bio (and cyto) compatibility properties. This review paper discusses several of the latest nanotechnology findings in regenerative medicine (also now called nanomedicine) as well as their relative levels of success.
未来的生物材料必须在最大限度地减少免疫反应和抑制感染的同时，增强组织再生。虽然组织工程学领域承诺开发可促进全身组织再生的材料，但这些承诺尚未成为现实。然而，由于纳米技术的出现，组织工程学已经取得了巨大的进展。具体来说，现在已经充分证实，通过采用新型纳米纹理表面特征，可以在几乎任何表面上实现增加的组织再生。许多研究报告称，纳米技术加速了各种再生疗法的发展，如骨骼、血管、心脏、软骨、膀胱和脑组织的再生疗法。已经研究了各种纳米结构聚合物和金属（合金）的生物（和细胞）相容性特性。本文综述了再生医学（现在也称为纳米医学）中几项最新的纳米技术研究成果及其相对的成功水平。
