Andersson Jonas, Boman Kurt, Jansson Jan-Håkan, Nilsson Torbjørn K, Lindahl Bernt
Department of Medicine and Geriatrics, Skellefteå County Hospital, Skellefteå, Sweden.
Biomarkers. 2008 Nov;13(7):671-9. doi: 10.1080/13547500802661266.
C-reactive protein (CRP) is a marker of metabolic and cardiovascular disease. To study the effects of lifestyle on CRP in a high-risk population we conducted a randomized controlled trial on 200 obese subjects (BMI > 27 kg m(-2)) with impaired glucose tolerance recruited from primary care settings. They were randomized to either a 1-month stay at a wellness centre focusing on diet, exercise and stress management (intervention group) or 30-60 min of oral and written information on lifestyle intervention (control group). A significant reduction of CRP was observed after 1 month and 1 year in the intervention group. They reduced their CRP levels more than the control group 1 year after intervention (p=0.004). In conclusion lifestyle intervention can decrease CRP in obese individuals with impaired glucose tolerance for up to 1 year. Further research is needed to evaluate whether the CRP level reduction translates into a decreased risk for cardiovascular morbidity.
C反应蛋白（CRP）是代谢和心血管疾病的一个标志物。为了研究生活方式对高危人群中CRP的影响，我们对从初级保健机构招募的200名糖耐量受损的肥胖受试者（体重指数>27 kg/m²）进行了一项随机对照试验。他们被随机分为两组，一组在专注于饮食、运动和压力管理的健康中心停留1个月（干预组），另一组接受30 - 60分钟关于生活方式干预的口头和书面信息（对照组）。干预组在1个月和1年后观察到CRP显著降低。干预1年后，他们的CRP水平下降幅度比对照组更大（p = 0.004）。总之，生活方式干预可使糖耐量受损的肥胖个体的CRP降低长达1年。需要进一步研究以评估CRP水平降低是否转化为心血管疾病发病率的降低。
