Dunn Jeff F, Tuor Ursula I, Kmech Jonn, Young Nicole A, Henderson Amy K, Jackson Jesse C, Valentine Pamela A, Teskey G Campbell
Experimental Imaging Centre, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
Magn Reson Med. 2009 Jan;61(1):222-8. doi: 10.1002/mrm.21803.
There is a need for acute and chronic stimulation of the brain within the MRI for studies of epilepsy, as well as deep brain stimulation for movement and behavioral disorders. This work describes the production and characteristics of carbon fiber-based electrodes for acute and chronic stimulation in the brain. Increasing MRI field strengths are making it increasingly difficult to introduce foreign objects without a susceptibility artifact. We describe the production of, and the characteristics of carbon fiber-based electrodes. These are biocompatible and can be implanted for chronic studies. We show the use of these electrodes at 9.4T for studying functional activation. Data are presented showing regional connectivity. Activation not only occurs near the electrode, but at sites distant and often contralateral to the electrode. In addition, there were sites showing strong negative activation to stimulation both with direct stimulation and during a kindling-associated seizure.
在磁共振成像（MRI）环境中，对于癫痫研究需要对大脑进行急性和慢性刺激，同时对于运动和行为障碍需要进行深部脑刺激。这项工作描述了用于大脑急性和慢性刺激的碳纤维基电极的制作及其特性。随着MRI场强的不断提高，在不产生磁化率伪影的情况下引入异物变得越来越困难。我们描述了碳纤维基电极的制作及其特性。这些电极具有生物相容性，可植入用于慢性研究。我们展示了这些电极在9.4T场强下用于研究功能激活的情况。给出的数据显示了区域连通性。激活不仅发生在电极附近，还发生在与电极距离较远且通常为对侧的部位。此外，在直接刺激以及在点燃相关癫痫发作期间，都有一些部位对刺激表现出强烈的负激活。
