Jupp Bianca, Williams John P, Tesiram Yasvir A, Vosmansky Milosh, O'Brien Terence J
The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia.
J Neurosci Methods. 2006 Jul 15;155(1):72-6. doi: 10.1016/j.jneumeth.2005.12.024. Epub 2006 Feb 8.
The rat electrical kindling model has been widely utilized in epilepsy research. This study aimed to identify the optimum "MRI compatible" bipolar stimulating and recording electrodes to enable serial MRI acquisition in this model. Two types of custom-made electrodes (gold and carbon) were compared with commercial platinum-iridium alloy electrodes for suitability based on size, effect on image quality and kindling induction. The custom-made gold electrodes, based on these parameters, were found to be most suitable. These electrodes enable the study of epileptogenesis utilizing MRI in this model of temporal lobe epilepsy (TLE).
大鼠电点燃模型已广泛应用于癫痫研究。本研究旨在确定最佳的“磁共振成像兼容”双极刺激和记录电极，以便在该模型中进行系列磁共振成像采集。基于尺寸、对图像质量的影响和点燃诱导情况，将两种定制电极（金电极和碳电极）与商用铂铱合金电极进行适用性比较。基于这些参数，发现定制的金电极最为合适。这些电极能够在该颞叶癫痫（TLE）模型中利用磁共振成像研究癫痫发生机制。
