Int J Cardiol. 2010 Jun 25;142(1):107-9. doi: 10.1016/j.ijcard.2008.11.109. Epub 2008 Dec 21.
ACEI and AT1 receptor antagonists are the drugs most consistently shown to reduce ADMA level in humans. Unfortunately, most of the human studies addressing the effect of pharmacotherapy on ADMA metabolism were accomplished on small patient subgroups and were relatively shortlasting. Besides, L-arginine was rarely measured in most studies, whereas L-arginine/ADMA ratio may be more important for NO synthase function than ADMA itself, and arginine concentration may be either increased or decreased by pharmacotherapy. We strongly believe that agents affecting ADMA more specifically (protein arginine methyltransferases inhibitors or dimethylarginine dimethylaminohydrolase inducers) deserve further investigation.
ACEI 和 AT1 受体拮抗剂是最能降低人类 ADMA 水平的药物。不幸的是，大多数针对药物治疗对 ADMA 代谢影响的人体研究都是在小的患者亚组中完成的，而且持续时间相对较短。此外，在大多数研究中很少测量 L-精氨酸，而 L-精氨酸/ADMA 比值可能比 ADMA 本身对一氧化氮合酶功能更为重要，而且药物治疗可能会增加或减少精氨酸浓度。我们坚信，更具体地影响 ADMA 的药物（蛋白精氨酸甲基转移酶抑制剂或二甲基精氨酸二甲氨基水解酶诱导剂）值得进一步研究。
