Trocha M, Szuba A, Merwid-Lad A, Sozański T
Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.
Pharmazie. 2010 Aug;65(8):562-71.
Asymmetric dimethylarginine (ADMA) is an endogenous methylated amino acid derived from arginine which can inhibit the activity of nitric oxide synthases. In various pathological states such as hypercholesterolemia, hyperglycemia, hyperhomocysteinemia, hypertension, coronary artery disease, heart failure, and stroke, plasma levels of ADMA may be increased and lead to inhibition of NO synthesis and endothelial dysfunction. Inhibition of ADMA synthesis or intensification of metabolism of this compound might indirectly lower ADMA. Antioxidants, estrogen, vitamin A, angiotensin converting enzyme inhibitors, angiotensin AT1 receptor antagonists, and also some hypolipemic, hypoglycemic and beta-adrenoreceptor blocking drugs decrease ADMA levels. In some situations like neurological disorders, decreased plasma levels of ADMA are noticed and drugs increasing the concentration of this compound could exert protective effects. It is reasonable to explore which drugs can increase or decrease ADMA levels and what their mechanism of that action is.
不对称二甲基精氨酸（ADMA）是一种源自精氨酸的内源性甲基化氨基酸，它能够抑制一氧化氮合酶的活性。在诸如高胆固醇血症、高血糖症、高同型半胱氨酸血症、高血压、冠状动脉疾病、心力衰竭和中风等各种病理状态下，ADMA的血浆水平可能会升高，并导致一氧化氮合成受到抑制以及内皮功能障碍。抑制ADMA合成或增强该化合物的代谢可能会间接降低ADMA水平。抗氧化剂、雌激素、维生素A、血管紧张素转换酶抑制剂、血管紧张素AT1受体拮抗剂，以及一些降血脂、降血糖和β-肾上腺素能受体阻断药物可降低ADMA水平。在某些情况下，如神经疾病，会观察到血浆中ADMA水平降低，而增加该化合物浓度的药物可能会发挥保护作用。探索哪些药物能够升高或降低ADMA水平以及它们的作用机制是合理的。
