0.05%丙酸氟替卡松保守治疗包茎：1185例男孩的临床研究
Conservative treatment of phimosis with fluticasone proprionate 0.05%: a clinical study in 1185 boys.
作者信息
Zavras Nick, Christianakis Efstratios, Mpourikas Demetrios, Ereikat Khalil
机构信息
Department of Paediatric Surgery, Penteli General Children's Hospital, 8 Hippocratous Str, 15236 P. Penteli, Athens, Greece.
出版信息
J Pediatr Urol. 2009 Jun;5(3):181-5. doi: 10.1016/j.jpurol.2008.11.006. Epub 2008 Dec 20.
OBJECTIVE
Circumcision has been the traditional method of choice in the treatment of boys with phimosis. Recently, several published studies worldwide have focused their interest on more conservative approaches in management of this condition. These studies advocate the use of topical steroids in the phimotic foreskin. We aimed to investigate the efficacy and safety of a medium potency corticosteroid in boys with different types of prepuce retractabilty.
PATIENTS AND METHODS
A prospective study was performed involving boys referred to our hospital for possible phimosis between January 2004 and February 2008. All were treated initially with fluticasone proprionate 0.05% for a period of 4-8 weeks. Patients were reassessed after 6 months of follow up.
RESULTS
A total of 1185 boys with a diagnosis of phimosis were treated with fluticasone proprionate 0.05%. Successful results were achieved in 1079 (91.1%) patients including boys with mild balanitis xerotica obliterans. No side effects were noticed.
CONCLUSION
Our results show that fluticasone proprionate 0.05%, a mild potent corticosteroid, is effective and safe in the treatment of boys with different types of phimosis.
目的
包皮环切术一直是治疗包茎男孩的传统首选方法。最近，全球范围内发表的几项研究将兴趣集中在对这种情况的更保守治疗方法上。这些研究主张在包茎包皮中使用局部类固醇。我们旨在研究一种中效皮质类固醇对不同类型包皮可退缩性男孩的疗效和安全性。
患者与方法
进行了一项前瞻性研究，纳入了2004年1月至2008年2月间因可能患有包茎而转诊至我院的男孩。所有患者最初均使用0.05%丙酸氟替卡松治疗4至8周。随访6个月后对患者进行重新评估。
结果
共有1185例诊断为包茎的男孩接受了0.05%丙酸氟替卡松治疗。1079例（91.1%）患者取得了成功结果，包括患有轻度闭塞性干燥性龟头炎的男孩。未观察到副作用。
结论
我们的结果表明，0.05%丙酸氟替卡松这种轻度强效皮质类固醇在治疗不同类型包茎男孩方面有效且安全。
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