Summers Thomas A, Lehman Michael B, Barner Ross, Royer Michael C
Department of Anatomic Pathology, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA.
Adv Anat Pathol. 2009 Jan;16(1):56-61. doi: 10.1097/PAP.0b013e3181915ff7.
Lupus mastitis (LM) is a rare presentation of lupus erythematosus profundus or lupus panniculitis, an unusual and rare clinical variant of lupus erythematosus itself in which the inflammatory reaction occurs primarily in the deep subcutaneous adipose. Although not required for diagnosis, essentially all cases of LM present with systemic or discoid lupus. The etiology is uncertain. Histologically it is defined by a lymphocytic lobular panniculitis and a characteristic hyaline sclerosis of the adipose tissue. Treatment is primarily medical due to exacerbation of disease by surgical intervention. A high index of suspicion, and familiarity of the histologic findings, is therefore required to make an accurate diagnosis and prevent further unwarranted diagnostic procedures. Herein, we provide a literature-based review of the clinical, radiologic, and pathologic findings of LM and its treatment and prognosis with the addition of a case for the literature.
狼疮性乳腺炎（LM）是深部红斑狼疮或狼疮性脂膜炎的一种罕见表现，而深部红斑狼疮或狼疮性脂膜炎本身是红斑狼疮一种不常见且罕见的临床变异型，其炎症反应主要发生在皮下深层脂肪组织。虽然诊断时并非必需，但基本上所有LM病例都伴有系统性或盘状红斑狼疮。病因尚不确定。组织学上，它的定义为淋巴细胞性小叶脂膜炎以及脂肪组织特有的透明样硬化。由于手术干预会使病情加重，所以主要采用药物治疗。因此，需要高度的怀疑指数以及对组织学发现的熟悉程度，才能做出准确诊断并避免进一步不必要的诊断程序。在此，我们基于文献对LM的临床、放射学和病理学发现及其治疗与预后进行综述，并补充一个文献病例。
