Nishanian P, Hofmann B, Wang Y, Jackson A L, Detels R, Fahey J L
Center for Interdisciplinary Research in Immunology and Disease (CIRID), UCLA School of Medicine.
AIDS. 1991 Jul;5(7):805-12. doi: 10.1097/00002030-199107000-00003.
To characterize CD8 T-cell activation during HIV-1 infection we measured serum soluble CD8 (sCD8) levels longitudinally in seroconverters and in individuals with established HIV infection who were in different stages of illness. CD8 T-cell activation occurs very early in HIV infection. Serum sCD8 levels were elevated in 91.5% of the first seropositive samples in seroconverters. Furthermore, CD8 T-cell activation persists throughout HIV infection. sCD8 predicted the occurrence of AIDS in HIV-seropositive individuals and so the addition of serum sCD8 levels to CD4 T-cell measurements increased the power in predicting the onset of AIDS. The serum level of sCD8 was particularly relevant to the prediction of subsequent CD4 T-cell fall relatively early in infection, for example, in the 3 years after seroconversion. However, later in HIV infection, for example within 2 years prior to development of AIDS, sCD8 levels were less predictive. sCD8 correlated with levels of beta 2-microglobulin and neopterin, which reflect activation of cell types other than CD8. Thus, serum sCD8 level can be a useful marker of specific CD8 T-cell activation, and is an independent predictor of prognosis in HIV infection.
为了描述HIV-1感染期间CD8 T细胞的激活情况，我们对血清转化者以及处于疾病不同阶段的已确诊HIV感染者的血清可溶性CD8（sCD8）水平进行了纵向测量。CD8 T细胞激活在HIV感染早期就会发生。在血清转化者中，91.5%的首次血清阳性样本中血清sCD8水平升高。此外，CD8 T细胞激活在整个HIV感染过程中持续存在。sCD8可预测HIV血清阳性个体中艾滋病的发生，因此在CD4 T细胞测量中加入血清sCD8水平可提高预测艾滋病发病的能力。血清sCD8水平与感染相对早期（例如血清转化后的3年内）后续CD4 T细胞下降的预测尤为相关。然而，在HIV感染后期，例如在发展为艾滋病前2年内，sCD8水平的预测性较差。sCD8与β2-微球蛋白和新蝶呤水平相关，这两者反映了CD8以外其他细胞类型的激活。因此，血清sCD8水平可作为特定CD8 T细胞激活的有用标志物，并且是HIV感染预后的独立预测指标。
