Grimes T M, King D J
Avian Dis. 1977 Jan-Mar;21(1):97-12.
Mortality was 60% when chickens without detectable maternal antibody to avian adenoviruses were inoculated intra-abdominally with 10(6) plaque-forming units of AMG 5(2a), a type-8 avian adenovirus. Other results were macroscopic and microscopic lesions in a wide range of organs, statistically significant depression of body weights, AMG 5(2a) virus in the liver and feces, and high virus-neutralizing antibody titers to AMG 5(2a). The disease produced was similar to that described in a previous report of AMG 5(2a) infection of chickens, and similar to inclusion body hepatitis as described in the literature. In contrast, similar inoculation of chickens with maternal antibody to type-8 avian adenovirus resulted in no mortality, lesions in the liver only, no depression of body weight, AMG 5(2a) virus in the feces only, and relatively low virus-neutralizing antibody titers. During this study a hemorrhagic-aplastic anemia syndrome occurred in both AMG 5(2a)-inoculated and control chickens in one trial. Pathologic, virologic, and serologic findings indicated that the spontaneously occurring disease was not caused by an avian adenovirus.
当对未检测到针对禽腺病毒的母源抗体的鸡腹腔内接种10(6)个噬斑形成单位的AMG 5(2a)（一种8型禽腺病毒）时，死亡率为60%。其他结果包括广泛器官出现大体和微观病变、体重出现统计学上显著下降、肝脏和粪便中存在AMG 5(2a)病毒以及针对AMG 5(2a)的高病毒中和抗体滴度。所产生的疾病与先前关于鸡AMG 5(2a)感染的报告中描述的疾病相似，也与文献中描述的包涵体肝炎相似。相比之下，对具有针对8型禽腺病毒母源抗体的鸡进行类似接种，结果没有死亡、仅肝脏出现病变、体重没有下降、仅粪便中存在AMG 5(2a)病毒以及相对较低的病毒中和抗体滴度。在这项研究期间，在一次试验中，接种AMG 5(2a)的鸡和对照鸡均出现了出血性再生障碍性贫血综合征。病理、病毒学和血清学结果表明，这种自发发生的疾病不是由禽腺病毒引起的。
