Chen Xiao-ping, Wu Juan, Peng Qing, Huang He, Mao Zhen-xing, Huang Yan, Jiang Ling-yun, Zhu Ye, Zheng Ting-lin, Zhou Xiao-mei, Li Hong-ping, Huang De-jia
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Aug;36(8):722-5.
To study the relationship between microalbuminuria and cognitive impairment in primary hypertensive patients.
A total of 200 hypertensive patients were included in this study. Blood pressure, body height and weight, total cholesterol, triglyceride, fasting plasma glucose, 2 hour-postprandial blood sugar, insulin level and urine protein were measured. Microalbuminuria and urine creatinine were determined in patients without proteinuria. The risk stratification of hypertension was evaluated. The cognitive function and calculate scores were tested by the Mini Mental State Examination (MMSE) and patients were divided into two groups: > 24-scores were classified as normal cognition group, < or = 24-scores as impaired cognition group.
Among the 200 hypertensive patients, proteinuria was detected in 25 patients. There was no significant difference in the cognitive function between patients with and without proteinuria (P > 0.05). There were significant differences on age, educational level, occupation, smoking, history of coronary heart disease, history of cerebrovascular disease, the risk stratification of hypertension, microalbuminuria/creatinine ratio, postprandial insulin level, cholesterol and diastolic blood pressure between normal cognition function group and impaired cognition function group (all P < 0.05). Multivariate logistic regression analysis showed that microalbuminuria, educational level and the risk stratification of hypertension were significantly correlated to cognition impairment (all P < 0.05).
Educational level, the risk stratification of hypertension and microalbuminuria are associated with cognitive impairment in this patient cohort.
研究原发性高血压患者微量白蛋白尿与认知功能障碍之间的关系。
本研究共纳入200例高血压患者。测量血压、身高、体重、总胆固醇、甘油三酯、空腹血糖、餐后2小时血糖、胰岛素水平和尿蛋白。对无蛋白尿的患者测定微量白蛋白尿和尿肌酐。评估高血压的风险分层。采用简易精神状态检查表（MMSE）测试认知功能并计算得分，患者被分为两组：得分>24分为认知正常组，得分≤24分为认知障碍组。
200例高血压患者中，25例检测到蛋白尿。有蛋白尿和无蛋白尿患者的认知功能无显著差异（P>0.05）。认知正常功能组和认知障碍功能组在年龄、教育程度、职业、吸烟、冠心病史、脑血管病史、高血压风险分层、微量白蛋白尿/肌酐比值、餐后胰岛素水平、胆固醇和舒张压方面存在显著差异（均P<0.05）。多因素逻辑回归分析显示，微量白蛋白尿、教育程度和高血压风险分层与认知障碍显著相关（均P<0.05）。
在该患者队列中，教育程度、高血压风险分层和微量白蛋白尿与认知障碍有关。
