Su Yanling, Chen Xiaoping, Huang Yan, Jiang Lingyun, Huang He
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Aug;26(4):856-60.
To explore the relationship between apolipoprotein E polymorphism and cognitive function in primary hypertension patients, we collected 200 Chinese primary hypertensive patients. Blood pressure (BP), heart rate (HR), height, body weight, waistline, hip circumference were measured. The Mini Mental State Examination (MMSE) was applied to test the cognitive function and compute score. Full-automatic bio-chemistry analyzer was used to determine total cholesterol (TC) and triglyeride (TG) and fasting glucose. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) was used for the analysis of the apolipoprotein E polymorphism. We found that in primary hypertension patients, the genotype frequency of epsilon3/4 and epsilon4/4 were significantly higher in the cognitive impairment group than that in the cognitive normal group. The allele frequency of e4 is obviously higher in the cognitive impairment group than that in the cognitive normal group. Age and epsilon4/4 genetype were positively correlated with hypertensive-cognitive impairment, while cultural level was negtively correlated with it. ApoEepsilon4 allele and age might be risk factors for the cognitive impairment in hypertensive patients. The epsilon4 homozygote (epsilon4/4) might be an important influencing factor for the progression of cognitive impairment.
为探讨原发性高血压患者载脂蛋白E基因多态性与认知功能之间的关系，我们收集了200例中国原发性高血压患者。测量了血压（BP）、心率（HR）、身高、体重、腰围、臀围。应用简易精神状态检查表（MMSE）测试认知功能并计算得分。使用全自动生化分析仪测定总胆固醇（TC）、甘油三酯（TG）和空腹血糖。采用聚合酶链反应-限制性片段长度多态性（PCR-RELP）分析载脂蛋白E基因多态性。我们发现，在原发性高血压患者中，认知障碍组ε3/4和ε4/4的基因型频率显著高于认知正常组。认知障碍组中ε4的等位基因频率明显高于认知正常组。年龄和ε4/4基因型与高血压性认知障碍呈正相关，而文化程度与之呈负相关。ApoEε4等位基因和年龄可能是高血压患者认知障碍的危险因素。ε4纯合子（ε4/4）可能是认知障碍进展的一个重要影响因素。
