Sicras-Mainar Antoni, Blanca-Tamayo Milagrosa, Navarro-Artieda Ruth, Pizarro-Paixa Israel, Gómez-Lus Centelles Susana
Dirección de Planificación. Badalona Serveis Assistencials, S.A. Badalona. Barcelona. España.
Aten Primaria. 2008 Dec;40(12):603-10. doi: 10.1016/s0212-6567(08)75693-2.
To evaluate the co-morbidity, health care use, economical impact, and availability of effective treatments used in generalised anxiety disorder (GAD) patients in a primary care setting (PCS).
A retrospective multicentre population-based study.
Five primary care clinics managed by Badalona Serveis Assistencials S.A., Barcelona, Spain.
Outpatient records of patients over 18 years managed at 5 PCSs during 2006. Patients with and without GAD were compared. In GAD patients, 4 groups were established for comparison, according to pharmacological prescription.
Main outcomes measures were general, reason/co-morbidity, health care use and primary care cost (visits, diagnostic/therapeutic tests, and drugs). We counted work absenteeism as an indirect cost. Pharmacological prescription was studied according to evidence-based recommendations and Spanish health-approved indications. The statistical analysis included a multivariate model: logistic regression, analysis of covariance (ANCOVA), P< .05. RESULTS. Of the 65 767 patients included, 4.6% (95% confidence interval [CI], 3.9-5.3) had GAD. Patients with/without GAD, the average episode/year was 6.1 versus 4.7 and attendance/year 10.0 versus 7.6; P< .001. GAD was associated with women (odds ratio [OR], 1.8), dyslipidemia (OR, 1.2), smoking (OR, 1.4), depression (OR, 1.2), and cerebrovascular accident (OR, 1.6) (P< .02). The mean direct cost/year adjusted by age, gender and morbidity load was euro686 versus euro557 (P< .001). GAD was associated with higher directs costs. The recommended treatment was followed in 40.1% of total patients (95% CI, 38.4-41.8).
Patients with GAD have greater co-morbidity and higher direct costs in PCS. Means designed to improve the recognition and treatment of these patients should be established in the PCS.
评估基层医疗环境(PCS)中广泛性焦虑症(GAD)患者的合并症、医疗保健利用情况、经济影响以及有效治疗方法的可及性。
一项基于人群的回顾性多中心研究。
由西班牙巴塞罗那的巴达洛纳社会服务公司管理的五家基层医疗诊所。
2006年期间在5家基层医疗中心接受管理的18岁以上患者的门诊记录。对患有和未患有广泛性焦虑症的患者进行比较。在广泛性焦虑症患者中,根据药物处方设立了4组进行比较。
主要结局指标包括一般情况、病因/合并症、医疗保健利用情况以及基层医疗费用(就诊次数、诊断/治疗检查和药物)。我们将旷工视为间接成本。根据循证医学建议和西班牙卫生部门批准的适应症对药物处方进行研究。统计分析包括多变量模型:逻辑回归、协方差分析(ANCOVA),P <.05。结果。在纳入的65767名患者中,4.6%(95%置信区间[CI],3.9 - 5.3)患有广泛性焦虑症。患有/未患有广泛性焦虑症的患者,平均每年发作次数分别为6.1次和4.7次,每年就诊次数分别为10.0次和7.6次;P <.001。广泛性焦虑症与女性(优势比[OR],1.8)、血脂异常(OR,1.2)、吸烟(OR,1.4)、抑郁症(OR,1.2)和脑血管意外(OR,1.6)相关(P <.02)。经年龄、性别和发病负荷调整后的平均每年直接成本为686欧元和557欧元(P <.001)。广泛性焦虑症与更高的直接成本相关。40.1%的患者(95% CI,38.4 - 41.8)遵循了推荐治疗方案。
在基层医疗环境中广泛性焦虑症患者有更多合并症和更高的直接成本。应在基层医疗环境中建立旨在改善对这些患者的识别和治疗的方法。