Arai Shozo, Matsui Yoshitaka, Fukuda Shigeo, Okada Hiroyuki, Onoe Sadao
Research Team for Production Diseases, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki 305-0856, Japan.
Res Vet Sci. 2009 Aug;87(1):111-4. doi: 10.1016/j.rvsc.2008.10.019. Epub 2008 Dec 19.
This study was carried out to evaluate the features of neurological dysfunction in experimentally-induced bovine spongiform encephalopathy (BSE)-infected cattle using brainstem auditory evoked potentials (BAEP). The progressive prolongation of peak latency of waves III and V was observed right-and-left bilaterally at the onset of neurological symptoms. The peak latency of wave V and the I-V interpeak latency (IPL) in BSE cattle 22 and 24 months after intracerebral inoculation were significantly (P<0.05) prolonged compared with the control cattle. In addition, the amplitude of the BAEP waves of the BSE cattle were low compared with the control cattle. Hearing loss occurred in the BSE cattle that showed advanced neurological symptoms such as tremor. It is thought that this BAEP data reflects a functional disorder in the central auditory nerve pathways characteristic of experimentally-induced BSE.
本研究旨在利用脑干听觉诱发电位（BAEP）评估实验性诱导感染牛海绵状脑病（BSE）的牛的神经功能障碍特征。在神经症状出现时，双侧左右均观察到波III和波V的峰潜伏期逐渐延长。脑内接种后22和24个月的BSE牛的波V峰潜伏期和I-V峰间潜伏期（IPL）与对照牛相比显著延长（P<0.05）。此外，BSE牛的BAEP波幅与对照牛相比偏低。在出现震颤等晚期神经症状的BSE牛中发生了听力损失。据认为，该BAEP数据反映了实验性诱导BSE所特有的中枢听觉神经通路的功能障碍。
