患有与HIV相关认知障碍的西班牙裔女性单核细胞和脑脊液中的抗氧化酶功能障碍。
Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment.
作者信息
Velázquez Ixane, Plaud Marinés, Wojna Valerie, Skolasky Richard, Laspiur Juliana Pérez, Meléndez Loyda M
机构信息
Department of Microbiology and Medical Zoology, University of Puerto Rico Medical Sciences Campus, Biomedical Building I, Suite 310, San Juan, 00935, Puerto Rico.
出版信息
J Neuroimmunol. 2009 Jan 3;206(1-2):106-11. doi: 10.1016/j.jneuroim.2008.10.013. Epub 2008 Dec 19.
Abstract
HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in CI by measures of expression and activity of Cu/Zn SOD, catalase, and Se-glutathione peroxidase in HAND. Our results showed that the function of these antioxidants was decreased in the CSF and monocytes of women with CI. These findings have important implications regarding their possible contribution to oxidative stress and in the diagnosis and therapy for HAND.
摘要
在抗逆转录病毒治疗时代，与人类免疫缺陷病毒（HIV）相关的认知神经障碍（HAND）很常见。脑脊液的蛋白质组学分析显示，认知功能受损（CI）的西班牙裔女性体内铜锌超氧化物歧化酶（Cu/Zn SOD）有表达。我们通过检测Cu/Zn SOD、过氧化氢酶和硒谷胱甘肽过氧化物酶在HAND中的表达和活性，来验证CI患者体内抗氧化酶能力降低这一假设。我们的结果表明，这些抗氧化剂的功能在CI女性的脑脊液和单核细胞中有所下降。这些发现对于它们可能对氧化应激的影响以及HAND的诊断和治疗具有重要意义。
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