Raupp P, von Kries R, Pfahl H G, Manz F
Department of Neonatology, Children's Hospital, University of Düsseldorf, Federal Republic of Germany.
JPEN J Parenter Enteral Nutr. 1991 Jul-Aug;15(4):469-73. doi: 10.1177/0148607191015004469.
In total parenteral nutrition (TPN) of premature infants, glycero- and glucose-phosphate have been recommended, and clinically used, because of their considerable compatibility with calcium. However, a systematic comparative in vitro assessment of the therapeutic potential and safety of these substances has not yet been provided. We investigated the stability of TPN solutions containing calcium-gluconate and glycero- or glucose-phosphate in high concentrations. Evaluation was performed by visual inspection, absorptiometry, light microscopy, measurement of pH, and determination of calcium concentration before and after microfiltration. Even under circumstances promoting precipitation of calcium and phosphate--such as body temperature, relatively high pH, and concentrations of calcium and phosphorus exceeding those necessary to provide intrauterine accretion rates, all but one of the examined TPN admixtures remained stable. Our data suggest that the use of glycero-phosphate, and particularly glucose-phosphate, together with calcium-gluconate, is an uncomplicated and safe procedure to administer simultaneously high amounts of calcium and phosphorus in TPN of premature infants.
在早产儿的全胃肠外营养（TPN）中，由于甘油磷酸酯和葡萄糖磷酸酯与钙具有良好的相容性，已被推荐并临床使用。然而，尚未对这些物质的治疗潜力和安全性进行系统的体外比较评估。我们研究了高浓度含葡萄糖酸钙和甘油磷酸酯或葡萄糖磷酸酯的TPN溶液的稳定性。通过目视检查、吸光光度法、光学显微镜、pH测量以及微滤前后钙浓度的测定进行评估。即使在促进钙和磷酸盐沉淀的情况下，如体温、相对较高的pH值以及钙和磷的浓度超过提供宫内生长速率所需的浓度，除一种受试TPN混合物外，其他所有混合物均保持稳定。我们的数据表明，在早产儿的TPN中，将甘油磷酸酯，尤其是葡萄糖磷酸酯与葡萄糖酸钙一起使用，是一种简单且安全的方法，可同时给予大量的钙和磷。
