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甘油磷酸钠治疗新生儿低磷血症

Sodium glycerophosphate in the treatment of neonatal hypophosphataemia.

作者信息

Costello I, Powell C, Williams A F

机构信息

Pharmacy Department, St George's Hospital, London.

出版信息

Arch Dis Child Fetal Neonatal Ed. 1995 Jul;73(1):F44-5. doi: 10.1136/fn.73.1.f44.

DOI:10.1136/fn.73.1.f44
PMID:7552597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2528378/
Abstract

Nineteen very low birthweight (mean (SD) gestational age 28 (3) weeks) were parenterally fed nutrition solutions containing inorganic calcium and phosphorus salts. All infants had hypophosphataemia. Plasma concentrations were maintained between 1.5 mmol/l and 2.2 mmol/l. Plasma phosphorus concentrations reached 1.5 mmol/l or greater in three patients after 12 hours, in a further nine patients after 36 hours, and in all patients by 60 hours. Changes in plasma calcium concentrations were not significant.

摘要

19名极低出生体重儿(平均(标准差)胎龄28(3)周)接受了含无机钙盐和磷酸盐的肠外营养溶液喂养。所有婴儿均有低磷血症。血浆浓度维持在1.5毫摩尔/升至2.2毫摩尔/升之间。3名患者在12小时后血浆磷浓度达到1.5毫摩尔/升或更高,另外9名患者在36小时后达到,所有患者在60小时时均达到。血浆钙浓度变化不显著。

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引用本文的文献

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Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use.在存在有机磷的情况下,钙离子浓度对新生儿全合一输液添加剂的物理化学相容性和稳定性的影响。
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本文引用的文献

1
Optimized calcium/phosphorus solubility in a parenteral nutrition solution containing dicarboxylic amino acids and cysteine.在含有二羧酸氨基酸和半胱氨酸的肠外营养溶液中优化钙/磷溶解度。
J Am Coll Nutr. 1986;5(5):459-66. doi: 10.1080/07315724.1986.10720149.
2
Bone disease in preterm infants.早产儿的骨骼疾病
Arch Dis Child. 1989 Oct;64(10 Spec No):1403-9. doi: 10.1136/adc.64.10_spec_no.1403.
3
Calcium and phosphorus solubility in neonatal intravenous feeding solutions.钙和磷在新生儿静脉喂养溶液中的溶解度。
Arch Dis Child. 1990 Apr;65(4 Spec No):352-3. doi: 10.1136/adc.65.4_spec_no.352.
4
Efficacy of calcium glycerophosphate vs conventional mineral salts for total parenteral nutrition in low-birth-weight infants: a randomized clinical trial.甘油磷酸钙与传统矿物盐用于低出生体重儿全肠外营养的疗效:一项随机临床试验。
Am J Clin Nutr. 1991 Nov;54(5):903-8. doi: 10.1093/ajcn/54.5.903.
5
Glycero- vs glucose-phosphate in parenteral nutrition of premature infants: a comparative in vitro evaluation of calcium/phosphorus compatibility.甘油磷酸与葡萄糖磷酸用于早产儿肠外营养的比较:钙/磷相容性的体外比较评估
JPEN J Parenter Enteral Nutr. 1991 Jul-Aug;15(4):469-73. doi: 10.1177/0148607191015004469.
6
Cysteine usage increases the need for acetate in neonates who receive total parenteral nutrition.对于接受全胃肠外营养的新生儿,使用半胱氨酸会增加对乙酸盐的需求。
Am J Clin Nutr. 1991 Sep;54(3):565-7. doi: 10.1093/ajcn/54.3.565.