Chen Chih J, Kuo Terry B J, Tseng Yi-Jhan, Yang Cheryl C H
Department of Urology, Hualien General Hospital, Department of Health, Executive Yuan, Taiwan.
Clin Neurophysiol. 2009 Feb;120(2):348-52. doi: 10.1016/j.clinph.2008.10.155. Epub 2008 Dec 19.
Patients with non-organic erectile dysfunction (ED) frequently present with syndromes involving systemic sympathovagal dysfunction. The linkage of ED to cardiac autonomic regulation is not well understood.
Forty-four men with non-organic ED and 38 healthy age-matched control subjects with ages ranging from 40 years to 69 years were recruited. These two groups were divided into three distinct age categories at 10-year intervals. Patients were divided into three different severity categories, among whom 35 patients received a two-month oral treatment of trazodone. Power spectral analysis of successive R-R intervals (RR) was performed to evaluate the variance (variance of RR-interval values), the high-frequency power (HF), and the ratio of low-frequency power to HF (LF/HF) of their heart rate variability (HRV).
Patients exhibited a significantly lower variance and HF, but a higher LF/HF compared to the control group across all age categories. The changes in variance and HF were severity dependent. In addition, all the HRV parameters of the patients with a satisfactory response after treatment have significantly improved.
The results indicate that patients with non-organic ED had significant cardiac sympathetic hyperactivity and severity-dependent cardiac vagal impairment.
Non-organic ED may be accompanied by an abnormality in cardiac autonomic regulation.
非器质性勃起功能障碍（ED）患者常伴有涉及全身交感-迷走神经功能障碍的综合征。ED与心脏自主神经调节之间的联系尚不清楚。
招募了44名患有非器质性ED的男性和38名年龄在40岁至69岁之间、年龄匹配的健康对照者。这两组被分为三个不同的年龄类别，间隔为10年。患者被分为三个不同的严重程度类别，其中35名患者接受了为期两个月的曲唑酮口服治疗。对连续的R-R间期（RR）进行功率谱分析，以评估其心率变异性（HRV）的方差（RR间期值的方差）、高频功率（HF）以及低频功率与HF的比值（LF/HF）。
在所有年龄类别中，患者的方差和HF均显著低于对照组，但LF/HF则更高。方差和HF的变化与严重程度相关。此外，治疗后有满意反应的患者的所有HRV参数均有显著改善。
结果表明，非器质性ED患者存在明显的心脏交感神经活动亢进和与严重程度相关的心脏迷走神经损伤。
非器质性ED可能伴有心脏自主神经调节异常。
