Rubenstein Edward, McLaughlin Theresa, Winant Richard C, Sanchez Agustin, Eckart Michael, Krasinska Karolina M, Chien Allis
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States.
Phytochemistry. 2009 Jan;70(1):100-4. doi: 10.1016/j.phytochem.2008.11.007. Epub 2008 Dec 26.
Azetidine-2-carboxylic acid (Aze) 1 is a non-protein amino acid present in sugar beets and in table beets (Beta vulgaris). It is readily misincorporated into proteins in place of proline 2 in many species, including humans, and causes numerous toxic effects as well as congenital malformations. Its role in the pathogenesis of disease in humans has remained unexplored. Sugar beet agriculture, especially in the Northern Hemisphere, has become widespread during the past 150 years, and now accounts for nearly 30% of the world's supply of sucrose. Sugar beet byproducts are also used as a dietary supplement for livestock. Therefore, this study was undertaken as an initial survey to identify Aze-containing links in the food chain. Herein, we report the presence of Aze 1 in three sugar beet byproducts that are fed to farm animals: sugar beet molasses, shredded sugar beet pulp, and pelleted sugar beet pulp.
氮杂环丁烷-2-羧酸（Aze）1是一种存在于甜菜和食用甜菜（Beta vulgaris）中的非蛋白质氨基酸。在包括人类在内的许多物种中，它很容易取代脯氨酸2而错误地掺入蛋白质中，并导致许多毒性作用以及先天性畸形。其在人类疾病发病机制中的作用尚未得到探索。在过去的150年里，甜菜种植业，尤其是在北半球，已经广泛传播，现在占世界蔗糖供应量的近30%。甜菜副产品也被用作牲畜的膳食补充剂。因此，本研究作为一项初步调查，旨在确定食物链中含Aze的环节。在此，我们报告了三种喂给农场动物的甜菜副产品中存在Aze 1：甜菜糖蜜、切碎的甜菜粕和甜菜粕颗粒。
